The public health use of fluoride in communal water supplies for the prevention of dental caries is accepted worldwide and the safety efficacy of its use in trace concentrations in this manner have been repeatedly documented. The proven cariostatic activity of fluoride has resulted in the widespread of fluoride-containing products to further and this increasing use of fluoride, it is not surprisingly that questions pertaining to the safety of this agent continue to be raised. The overall goal of this Program Project is to develop additional scientific information to assure the continued safe use of fluoride for dental public health. The Program involves three projects with the appropriate support provided by three core units for administration, biostatistics, and laboratory analyses. Project #1 is designed to investigate the possible pharmacologic and genotoxic effects of fluoride associated with lifetime ingestion of optimal or elevated levels of fluoride in the drinking water, effects of fluoride ingestion in medically- compromised children and adults afflicted with diabetes or chronic renal failure, and the effects of massive dosages of fluoride used to treat osteoporosis. Project #2 utilizes controlled animal models to investigate the impact of various medically-compromising conditions (i.e., aging, diabetes, renal failure and malnutrition) upon the pharmologic effects of fluoride. Project #4 will investigate the effect of chronic nutritional inadequacies upon the pharmacologic effects of fluoride in population groups residing The Peoples Republic of China and in Ecuador.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Research Program Projects (P01)
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Special Emphasis Panel (SRC (09))
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Indiana University-Purdue University at Indianapolis
Schools of Dentistry
United States
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Jackson, R D; Kelly, S A; Katz, B et al. (1999) Dental fluorosis in children residing in communities with different water fluoride levels: 33-month follow-up. Pediatr Dent 21:248-54
Chachra, D; Turner, C H; Dunipace, A J et al. (1999) The effect of fluoride treatment on bone mineral in rabbits. Calcif Tissue Int 64:345-51
Dunipace, A; Brizendine, E; Wilson, M et al. (1998) Effect of chronic fluoride exposure in uremic rats. Nephron 78:96-103
Dunipace, A J; Brizendine, E J; Wilson, M E et al. (1998) Chronic fluoride exposure does not cause detrimental, extraskeletal effects in nutritionally deficient rats. J Nutr 128:1392-400
Turner, C H; Garetto, L P; Dunipace, A J et al. (1997) Fluoride treatment increased serum IGF-1, bone turnover, and bone mass, but not bone strength, in rabbits. Calcif Tissue Int 61:77-83
Jackson, R D; Kelly, S A; Noblitt, T W et al. (1997) Lack of effect of long-term fluoride ingestion on blood chemistry and frequency of sister chromatid exchange in human lymphocytes. Environ Mol Mutagen 29:265-71
Turner, C H; Takano, Y; Hirano, T (1996) Reductions in bone strength after fluoride treatment are not reflected in tissue-level acoustic measurements. Bone 19:603-7
Turner, C H; Owan, I; Brizendine, E J et al. (1996) High fluoride intakes cause osteomalacia and diminished bone strength in rats with renal deficiency. Bone 19:595-601
Dunipace, A J; Wilson, C A; Wilson, M E et al. (1996) Absence of detrimental effects of fluoride exposure in diabetic rats. Arch Oral Biol 41:191-203
Jackson, R D; Kelly, S A; Katz, B P et al. (1995) Dental fluorosis and caries prevalence in children residing in communities with different levels of fluoride in the water. J Public Health Dent 55:79-84

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