The Center for Ulcer Research and Education (CURE) has two overall objectives. The first is to find, through research, the causes and the best methods for preventing, diagnosing, and treating peptic ulcer. The second is to disseminate information about peptic ulcer to health professionals and to the public. In support of these objectives, the Center engages in these activities: 1) Conducts interdisciplinary research on peptic ulcer disease both under Center auspices and through collaboration with outside institutions and researchers. 2) Disseminates research findings by means of professional publications and participation in scientific meetings. 3) Sponsors and participates in programs to educate scientists, physicians, other health professionals and the public about the causes, treatment, and prevention of peptic ulcer. Center individual and collaborative research efforts encompass many levels of investigation, including basic cell biology, physiology and pathophysiology of gastrointestinal secretions, mechanisms responsible for damage of the gastric and intestinal mucosa, epidemiology and genetics of ulcer disease and controlled trials of pharmacological agents and new treatment techniques. Educational activities include: sponsorship of and participation in international, national and local scientific conferences, symposia and seminars; a visiting scientist program; training of postdoctoral fellows; a physician continuing education program and public informational efforts.

Project Start
1979-04-01
Project End
1989-03-31
Budget Start
1985-12-01
Budget End
1986-11-30
Support Year
13
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Lee, E A; Weiss, S L; Lam, M et al. (1998) A method for assaying intestinal brush-border sucrase in an intact intestinal preparation. Proc Natl Acad Sci U S A 95:2111-6
Hammond, K A; Lloyd, K C; Diamond, J (1996) Is mammary output capacity limiting to lactational performance in mice? J Exp Biol 199:337-49
Secor, S M; Stein, E D; Diamond, J (1994) Rapid upregulation of snake intestine in response to feeding: a new model of intestinal adaptation. Am J Physiol 266:G695-705
Ferraris, R P; Diamond, J M (1993) Crypt/villus site of substrate-dependent regulation of mouse intestinal glucose transporters. Proc Natl Acad Sci U S A 90:5868-72
Ferraris, R P; Villenas, S A; Diamond, J (1992) Regulation of brush-border enzyme activities and enterocyte migration rates in mouse small intestine. Am J Physiol 262:G1047-59
Buddington, R K; Diamond, J (1992) Ontogenetic development of nutrient transporters in cat intestine. Am J Physiol 263:G605-16
Ferraris, R P; Villenas, S A; Hirayama, B A et al. (1992) Effect of diet on glucose transporter site density along the intestinal crypt-villus axis. Am J Physiol 262:G1060-8
Ferraris, R P; Diamond, J (1992) Crypt-villus site of glucose transporter induction by dietary carbohydrate in mouse intestine. Am J Physiol 262:G1069-73
Buddington, R K; Chen, J W; Diamond, J M (1991) Dietary regulation of intestinal brush-border sugar and amino acid transport in carnivores. Am J Physiol 261:R793-801
Tari, A; Wu, V; Sumii, M et al. (1991) Regulation of rat gastric H+/K(+)-ATPase alpha-subunit mRNA by omeprazole. Biochim Biophys Acta 1129:49-56

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