Abstract

Pathogenesis of calcium oxalate stones is under study. Serum PTH and 1,25(OH)2D3 and nephrogenous cyclic AMP are being measured along with response to low calcium diet and thiazide in patients with idiopathic hypercalciuria. Urine saturation and crystal growth inhibition are being measured in stone formers, in response to various forms of treatment. The factors that influence the ability of crystallization to occur on the surface of the urothelium, specifically the effects of urothelial injury on the deposition and attachment of calcium oxalate crystals, is being studied.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK033949-07
Application #
3095331
Study Section
(ADDK)
Project Start
1983-09-01
Project End
1992-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
7
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Kimmel, P L; Langman, C B; Bognar, B et al. (2001) Zinc nutritional status modifies renal osteodystrophy in uremic rats. Clin Nephrol 56:445-58
Favus, M J; Pak, C (2001) Evidence for absorption of ionic calcium and soluble calcium complexes by the duodenum and cecum in the rat. Am J Ther 8:425-31
Schneider, G B; Relfson, M; Langman, C B (1994) Effects of 1,25-dihydroxyvitamin D3 on bone resorption and natural immunity in osteopetrotic (ia) rats. J Bone Miner Res 9:585-91
Li, X Q; Tembe, V; Horwitz, G M et al. (1993) Increased intestinal vitamin D receptor in genetic hypercalciuric rats. A cause of intestinal calcium hyperabsorption. J Clin Invest 91:661-7
Deganello, S (1993) The interaction between nephrocalcin and Tamm-Horsfall proteins with calcium oxalate dihydrate. Scanning Microsc 7:1111-8
Kimmel, P L; Gubish, C T; Watkins, D W et al. (1992) Zinc nutritional status modulates the response of 1,25-dihydroxycholecalciferol to calcium depletion in rats. J Nutr 122:1576-81
Kimmel, P L; Watkins, D W; Gubish, C T et al. (1991) Zinc nutritional status modulates the 1,25-(OH)2D. Response in uremic rats. Miner Electrolyte Metab 17:307-14
Chabala, J M; Levi-Setti, R; Bushinsky, D A (1991) Alteration in surface ion composition of cultured bone during metabolic, but not respiratory, acidosis. Am J Physiol 261:F76-84
Deganello, S (1991) Interaction between nephrocalcin and calcium oxalate monohydrate: a structural study. Calcif Tissue Int 48:421-8
Pensler, J M; Langman, C B; Radosevich, J A et al. (1990) Sex steroid hormone receptors in normal and dysplastic bone disorders in children. J Bone Miner Res 5:493-8

Showing the most recent 10 out of 23 publications