This core will provide support for all four projects by performing the animal experimentsproposed by each project that utilize different models of experimental colitis.The core's main functions will be:1) to generate transgenic and knockout and transgenic animals in collaboration with theMouse Genetics Facility.2) to genotype and expand lines from transgenic founders and knockouts.3) to backcross and intercross multiple lines of transgenic and knockout mice.4) to assist with the experimental colitis models.The Animal Core will take advantage of existing facilities in the Center for ComparativeMedicine and Surgery (CCMS) at the Mount Sinai School of Medicine. This is a centralized,shared resource facility that provides veterinary, animal maintenance, and research supportto investigators engaged in a variety of research utilizing animal studies. The program isfully accredited by the American Association of Laboratory Animal Care, International. All ofthe proposed animal experiments will take place in the state-of-the-art barrier facilitylocated on the SC level of the East Building. This is a rodents only facility that offersindividually ventilated cages and a fully automated watering system. The Core will providethe technical expertise and support, as well as the necessary equipment and reagentsneeded for performing all study-related manipulations in mice.
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