Abstract

It is the overall goal of this project to develop a number of different biochemical loci for studying the effects of exogenous perturbants. These systems include the control of DNA replication, recombination and repair; a variety of metabolic control points influencing folate metabolism, cell membrane and glycogen biosynthesis, specific membrane receptors and finally those differentiating cellular systems which can influence antibody diversity. The effects of viruses, transfecting or transforming DNA, nutritional states, heavy metals, chemotherapeutic agents, mutagens and carcinogens will be examined at some of these functional biochemical loci.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES003131-03
Application #
3095859
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1983-04-01
Project End
1987-03-31
Budget Start
1985-04-01
Budget End
1987-03-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Morris, S; Huang, P C (1987) Transient response of amplified metallothionein genes in CHO cells to induction by alpha interferon. Mol Cell Biol 7:600-5
Huang, P C; Morris, S; Dinman, J et al. (1987) Role of metallothionein in detoxification and tolerance to transition metals. Experientia Suppl 52:439-46