Abstract

This program project consists of five experimental projects: 1) the development of an animal model for the carcinogenesis of inhaled benzene will be attempted by treating rats and mice to various exposure regimes of benzene vapor and by combining exposure of benzene with known leukemogenic agents; 2) the development of an animal model for the carcinogenesis of inhaled arsenic compounds will be attempted by exposing rats to a combination of arsenic trioxide aerosol and sulfur dioxide and by intratracheally instilling the components of Bordeaux mixture into rats; 3) the effect of fiber length on asbestos carcinogenicity will be studied by exposing rats to two different lengths of asbestos fibers which have the same aerodynamic mass median diameters. The development of lung damage will be monitored in vivo during the course of the exposures: 4) the interaction of atmospheres of HCl plus HCHO with DNA will be studied by measuring DNA damage by means of the S-1 nuclease assay in skin and nasal epidermal cells, as well as bacteria; and, 5) the amount of BCME and other alkylating agents in known, tumorigenic atmospheres of HCl plus HCHO will be determined by gas chromatographic and mass spectrometric techniques.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES003563-07
Application #
3095887
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1984-12-01
Project End
1987-11-30
Budget Start
1985-12-01
Budget End
1986-11-30
Support Year
7
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

Rich, D Q; Yiin, L M; Rhoads, G G et al. (1999) A field comparison of two methods for sampling lead in household dust. J Expo Anal Environ Epidemiol 9:106-12
Li, F; Solomon, J J; Mukai, F et al. (1990) In vitro reactions of isopropyl methanesulfonate with DNA and with 2'-deoxyribonucleosides. Cancer Biochem Biophys 11:253-64
Segal, A; Solomon, J J; Mukai, F (1990) In vitro reactions of glycidol with pyrimidine bases in calf thymus DNA. Cancer Biochem Biophys 11:59-67
Solomon, J J; Segal, A (1989) DNA adducts of propylene oxide and acrylonitrile epoxide: hydrolytic deamination of 3-alkyl-dCyd to 3-alkyl-dUrd. Environ Health Perspect 81:19-22
Segal, A; Sellakumar, A (1989) Inducibility of thymic lymphomas in female Hsd: (ICR)BR mice following subcutaneous injection of ethyl- and isopropyl methanesulfonate. Cancer Lett 44:199-204
Snyder, C A; Sellakumar, A R; James, D J et al. (1988) The carcinogenicity of discontinuous inhaled benzene exposures in CD-1 and C57Bl/6 mice. Arch Toxicol 62:331-5
Solomon, J J; Mukai, F; Fedyk, J et al. (1988) Reactions of propylene oxide with 2'-deoxynucleosides and in vitro with calf thymus DNA. Chem Biol Interact 67:275-94
Hochwalt, A E; Solomon, J J; Garte, S J (1988) Mechanism of H-ras oncogene activation in mouse squamous carcinoma induced by an alkylating agent. Cancer Res 48:556-8
Snyder, C A; Valle-Paul, C (1987) Isopropyl methanesulfonate is a potent red cell hematotoxicant. Toxicol Lett 36:61-6
Snyder, C A; Bowers, A B (1987) A new inhalation exposure system for the determination of inhaled doses in laboratory rats. Arch Toxicol 61:3-6

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