Abstract

Molecular Biomarkers for Environmental Carcinogens The long-term goals of this program project are to develop and validate molecular biomarkers reflective of exposure and risk from environmental carcinogens and to use these biomarkers for the design and implementation of prevention strategies in community settings. Several underlying public health based beliefs provide credence for attainment of these goals including, that there are sub-sets of high-risk people within populations that are most susceptible for disease. Thus, methods that can identify these high-risk individuals with high specificity and selectivity will greatly facilitate the implementation of a spectrum of targeted prevention techniques directed towards reducing individual risk. In total, the impact of molecular biomarker research ranges from exposure assessment, risk assessment and management, to clinical trials. This continuing program project consists of three project areas and two cores. They are : Molecular Biomarkers for Human Liver Cancer; Development and Application of Biomarkers to Molecular Interventions in Aflatoxin-Exposed Individuals; Molecular Biomarkers for Exposure and Susceptibility in Human Colon Cancer; Biostatistics/Epidemiology Core and Administrative Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
2P01ES006052-05
Application #
2018439
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1993-04-07
Project End
2002-05-31
Budget Start
1997-06-01
Budget End
1998-05-31
Support Year
5
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Chen, Taoyang; Qian, Gengsun; Fan, Chunsun et al. (2018) Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer. Hepatoma Res 4:
Yang, Li; Palliyaguru, Dushani L; Kensler, Thomas W (2016) Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane. Semin Oncol 43:146-153
Watson, Sinead; Chen, Gaoyun; Sylla, Abdoulaye et al. (2016) Dietary exposure to aflatoxin and micronutrient status among young children from Guinea. Mol Nutr Food Res 60:511-8
Ravindra, Kodihalli C; Trudel, Laura J; Wishnok, John S et al. (2016) Hydroxyphenylation of Histone Lysines: Post-translational Modification by Quinone Imines. ACS Chem Biol 11:1230-7
Chawanthayatham, Supawadee; Thiantanawat, Apinya; Egner, Patricia A et al. (2015) Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change. Int J Cancer 136:1254-62
Castelino, Jovita M; Routledge, Michael N; Wilson, Shona et al. (2015) Aflatoxin exposure is inversely associated with IGF1 and IGFBP3 levels in vitro and in Kenyan schoolchildren. Mol Nutr Food Res 59:574-81
Nachman, Rebecca M; Fox, Stephen D; Golden, W Christopher et al. (2015) Serial Free Bisphenol A and Bisphenol A Glucuronide Concentrations in Neonates. J Pediatr 167:64-9
Chao, Ming-Wei; Erkekoglu, P?nar; Tseng, Chia-Yi et al. (2015) Protective effects of ascorbic acid against the genetic and epigenetic alterations induced by 3,5-dimethylaminophenol in AA8 cells. J Appl Toxicol 35:466-77
Techapiesancharoenkij, Nirachara; Fiala, Jeannette L A; Navasumrit, Panida et al. (2015) Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1. Toxicol Appl Pharmacol 282:52-60
Shirima, Candida P; Kimanya, Martin E; Routledge, Michael N et al. (2015) A prospective study of growth and biomarkers of exposure to aflatoxin and fumonisin during early childhood in Tanzania. Environ Health Perspect 123:173-8

Showing the most recent 10 out of 234 publications