Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL041898-08
Application #
2220190
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1989-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1998-06-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Florida
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Schroeder, B; Boyle, M D; Sheerin, B R et al. (1999) Species specificity of plasminogen activation and acquisition of surface-associated proteolytic activity by group C streptococci grown in plasma. Infect Immun 67:6487-95
Winram, S B; Lottenberg, R (1998) Site-directed mutagenesis of streptococcal plasmin receptor protein (Plr) identifies the C-terminal Lys334 as essential for plasmin binding, but mutation of the plr gene does not reduce plasmin binding to group A streptococci. Microbiology 144 ( Pt 8):2025-35
Donabedian, H; Boyle, M D (1998) Clot formation by group A streptococci. Infect Immun 66:2362-4
D'Costa, S S; Wang, H; Metzger, D W et al. (1997) Group A streptococcal isolate 64/14 expresses surface plasmin-binding structures in addition to Plr. Res Microbiol 148:559-72
Boyle, M D; Lottenberg, R (1997) Plasminogen activation by invasive human pathogens. Thromb Haemost 77:1-10
Christner, R; Li, Z; Raeder, R et al. (1997) Identification of key gene products required for acquisition of plasmin-like enzymatic activity by group A streptococci. J Infect Dis 175:1115-20
Winram, S B; Lottenberg, R (1996) The plasmin-binding protein Plr of group A streptococci is identified as glyceraldehyde-3-phosphate dehydrogenase. Microbiology 142 ( Pt 8):2311-20
Christner, R B; Boyle, M D (1996) Role of staphylokinase in the acquisition of plasmin(ogen)-dependent enzymatic activity by staphylococci. J Infect Dis 173:104-12
Wang, H; Lottenberg, R; Boyle, M D (1995) Analysis of the interaction of group A streptococci with fibrinogen, streptokinase and plasminogen. Microb Pathog 18:153-66
Wang, H; Lottenberg, R; Boyle, M D (1995) A role for fibrinogen in the streptokinase-dependent acquisition of plasmin(ogen) by group A streptococci. J Infect Dis 171:85-92

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