Abstract

The principal goal of the Molecular Biomarkers Core is to identify patterns of altered gene expression that form a significant association with autism in human populations, or which are coupled to specific environmental factors in animal models. The core will utilize both broad-spectrum and focused microarrays to support the human and animal studies described in Research Projects I-III. To meet these needs, Core II will provide uniform handling, extraction, and isolation of mRNA from tissue samples generated by Center investigators. In addition, the core will use both human and mouse genomic libraries to create targeted microarrays. An essential component of the Core s efforts will be to further develop methods of analysis for microarray data in an effort to both better define, and reduce the errors associated with the interpretation of microarray information.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
1P01ES011269-01
Application #
6546117
Study Section
Special Emphasis Panel (ZES1)
Project Start
2001-09-30
Project End
2006-09-29
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Rose, Destanie R; Yang, Houa; Serena, Gloria et al. (2018) Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms. Brain Behav Immun 70:354-368
Zheng, Jing; Chen, Juan; Zou, Xiaohan et al. (2018) Saikosaponin d causes apoptotic death of cultured neocortical neurons by increasing membrane permeability and elevating intracellular Ca2+ concentration. Neurotoxicology 70:112-121
Shin, Hyeong-Moo; Schmidt, Rebecca J; Tancredi, Daniel et al. (2018) Prenatal exposure to phthalates and autism spectrum disorder in the MARBLES study. Environ Health 17:85
Keil, Kimberly P; Miller, Galen W; Chen, Hao et al. (2018) PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms. Arch Toxicol 92:3163-3173
Zheng, Jing; McKinnie, Shaun M K; El Gamal, Abrahim et al. (2018) Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics. Environ Sci Technol 52:5469-5478
Chen, Xiaopeng; Walter, Kyla M; Miller, Galen W et al. (2018) Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr 32:e4185
Jones, Karen L; Van de Water, Judy (2018) Maternal autoantibody related autism: mechanisms and pathways. Mol Psychiatry :
Kerin, Tara; Volk, Heather; Li, Weiyan et al. (2018) Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder. J Autism Dev Disord 48:137-150
Miller, Galen W; Chandrasekaran, Vidya; Yaghoobi, Bianca et al. (2018) Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity. Neurotoxicology 67:102-111
Edmiston, Elizabeth; Jones, Karen L; Vu, Tam et al. (2018) Identification of the antigenic epitopes of maternal autoantibodies in autism spectrum disorders. Brain Behav Immun 69:399-407

Showing the most recent 10 out of 327 publications