Abstract

This is a Program Project to further elucidate the hypothalamic control over gonadotropin and prolactin secretion. The Program Project is divided into six Projects which are the following: Project I consists of further studies on the production and action of LHRH; Project II consists of an evaluation of the role of brain peptides in control of gonadotropin and prolactin release; Project III is a study of monoaminergic, peptidergic and steroidal interactions in the hypothalamic control of LH and prolactin release; Project IV is a study of the neuroendocrinology of puberty and sexual development; Project V is an evaluation of the physiology and functional morphology of peptide neurons; and Project VI is an examination of the factors affecting hypothalamic secretion of LHRH. The Program Project is supported by three Cores which consist of a Radioimmunoassay Core I, Histology Core II and Administrative Core III. It is hoped that the results of these interdisciplinary studies will shed much further light on the operation of the hypothalamic pituitary unit which regulates secretion of gonadotropins and prolactin.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD009988-12
Application #
3096649
Study Section
Population Research and Training Committee (HDPR)
Project Start
1977-02-01
Project End
1990-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
12
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Type
Overall Medical
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Franci, C R; Anselmo-Franci, J A; McCann, S M (1997) Angiotensinergic neurons physiologically inhibit prolactin, growth hormone, and thyroid-stimulating hormone, but not adrenocorticoptropic hormone, release in ovariectomized rats. Peptides 18:971-6
Kentroti, S; McCann, S M (1996) Role of dopamine in the inhibitory control of growth hormone and prolactin release by gastrin-releasing peptide. Brain Res Bull 39:201-4
Kentroti, S; McCann, S M (1994) Determination of the structural requirements for the inhibitory action of gastrin-releasing peptide on growth hormone release. Brain Res Bull 33:99-103
Franci, C R; Anselmo-Franci, J A; Kozlowski, G P et al. (1993) Actions of endogenous vasopressin and oxytocin on anterior pituitary hormone secretion. Neuroendocrinology 57:693-9
Aguila, M C; McCann, S M (1993) Growth hormone increases somatostatin release and messenger ribonucleic acid levels in the rat hypothalamus. Brain Res 623:89-94
Reznikov, A G; McCann, S M (1993) Effects of neuropeptide Y on gonadotropin and prolactin release in normal, castrated or flutamide-treated male rats. Neuroendocrinology 57:1148-54
Wong, M; Moss, R L (1992) Modulation of single-unit activity in the rat medial amygdala by neurotransmitters, estrogen priming, and synaptic inputs from the hypothalamus and midbrain. Synapse 10:94-102
Karanth, S; Marubayashi, U; McCann, S M (1992) Influence of dopamine on the altered release of prolactin, luteinizing hormone, and follicle-stimulating hormone induced by interleukin-2 in vitro. Neuroendocrinology 56:871-80
Franci, C R; Anselmo-Franci, J A; McCann, S M (1992) The role of endogenous atrial natriuretic peptide in resting and stress-induced release of corticotropin, prolactin, growth hormone, and thyroid-stimulating hormone. Proc Natl Acad Sci U S A 89:11391-5
Lephart, E D; Simpson, E R; McPhaul, M J et al. (1992) Brain aromatase cytochrome P-450 messenger RNA levels and enzyme activity during prenatal and perinatal development in the rat. Brain Res Mol Brain Res 16:187-92

Showing the most recent 10 out of 145 publications