Abstract

The primary objective of the Zebrafish Facility is to support researchers using zebrafish to study vertebrate genefics, genomics, and development by employing expert husbandry techniques, supplying efficient and fimely services, and fostering a helpful, cooperative environment. This Core accomplishes these goals by providing the following services: (1) husbandry and feeding of adult fish, (2) husbandry and rearing of embryos and larvae, (3) provision of staged embryos, (4) sperm cryopreservation, (5) database tracking of all fish stocks and frozen sperm, (6) high through-put quaranfined screening for mutafions in fish from other facilities, (7) procedure rooms and equipment for embryo microinjecfion, and (8) advice and training on fish husbandry and facility set-up. Because our Zebrafish Facility has recently been expanded to provicle more procedure space, we are now adding a new services to the Zebrafish Facility, derivafion and maintenance of germ-free embryos and larvae.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD022486-27
Application #
8737031
Study Section
Special Emphasis Panel (ZHD1-DSR-Y)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
27
Fiscal Year
2014
Total Cost
$304,132
Indirect Cost
$94,386

  Institution

Name
University of Oregon
Department
Type
DUNS #
948117312
City
Eugene
State
OR
Country
United States
Zip Code
97403

  Publications

Logan, Savannah L; Thomas, Jacob; Yan, Jinyuan et al. (2018) The Vibrio cholerae type VI secretion system can modulate host intestinal mechanics to displace gut bacterial symbionts. Proc Natl Acad Sci U S A 115:E3779-E3787
Ganz, J; Baker, R P; Hamilton, M K et al. (2018) Image velocimetry and spectral analysis enable quantitative characterization of larval zebrafish gut motility. Neurogastroenterol Motil 30:e13351
Ferreira, Carlos R; Xia, Zhi-Jie; Clément, Aurélie et al. (2018) A Recurrent De Novo Heterozygous COG4 Substitution Leads to Saul-Wilson Syndrome, Disrupted Vesicular Trafficking, and Altered Proteoglycan Glycosylation. Am J Hum Genet 103:553-567
Logan, Savannah L; Dudley, Christopher; Baker, Ryan P et al. (2018) Automated high-throughput light-sheet fluorescence microscopy of larval zebrafish. PLoS One 13:e0198705
Clément, Aurélie; Blanco-Sánchez, Bernardo; Peirce, Judy L et al. (2018) Cog4 is required for protrusion and extension of the epithelium in the developing semicircular canals. Mech Dev :
Parthasarathy, Raghuveer (2018) Monitoring microbial communities using light sheet fluorescence microscopy. Curr Opin Microbiol 43:31-37
Troll, Joshua V; Hamilton, M Kristina; Abel, Melissa L et al. (2018) Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling. Development 145:
Dona, Margo; Slijkerman, Ralph; Lerner, Kimberly et al. (2018) Usherin defects lead to early-onset retinal dysfunction in zebrafish. Exp Eye Res 173:148-159
Blanco-Sánchez, Bernardo; Clément, Aurélie; Fierro Jr, Javier et al. (2018) Grxcr1 Promotes Hair Bundle Development by Destabilizing the Physical Interaction between Harmonin and Sans Usher Syndrome Proteins. Cell Rep 25:1281-1291.e4
Rolig, Annah S; Sweeney, Emily Goers; Kaye, Lila E et al. (2018) A bacterial immunomodulatory protein with lipocalin-like domains facilitates host-bacteria mutualism in larval zebrafish. Elife 7:

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