Abstract

This core will gather all of the psychometric and behavioral assessments for Projects I-III. It will evaluate 150 persons with autism, 125 controls, and more than 90 family members over a five year period with between 70 and 120 subjects evaluated each year (approximately 20 in Year- 05). Subject with autism will be screened on CARS, Vineland, CBCL, and PPVT, followed by the ADI-R and the ADOS-G. Preschoolers will get an EEG, and the school age group will get a Tanner evaluation and blood levels of estradiol and testosterone. Control groups will be screened with CBCL, Vineland, and SNAP-IV-C. Clinical levels on any of these will rule out the subject. The core instruments involve a history and physical and neuroexaminations, intelligence testing, (Binet, Bayley, and WIAT), three language tests and a language sample, executive function measures, and the ESCS for pragmatics and joint attention.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD035458-03
Application #
6302045
Study Section
Project Start
2000-03-01
Project End
2001-02-28
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
3
Fiscal Year
2000
Total Cost
$219,623
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Fujikawa-Brooks, Sharon; Isenberg, A Lisette; Osann, Kathryn et al. (2010) The effect of rate stress on the auditory brainstem response in autism: a preliminary report. Int J Audiol 49:129-40
Ramanathan, Subhadra; Woodroffe, Abigail; Flodman, Pamela L et al. (2004) A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R. BMC Med Genet 5:10
Palmer, Abraham A; Breen, Laura L; Flodman, Pamela et al. (2003) Identification of quantitative trait loci for prepulse inhibition in rats. Psychopharmacology (Berl) 165:270-9
Smith, M; Woodroffe, A; Smith, R et al. (2002) Molecular genetic delineation of a deletion of chromosome 13q12-->q13 in a patient with autism and auditory processing deficits. Cytogenet Genome Res 98:233-9
Smith, M; Escamilla, J R; Filipek, P et al. (2001) Molecular genetic delineation of 2q37.3 deletion in autism and osteodystrophy: report of a case and of new markers for deletion screening by PCR. Cytogenet Cell Genet 94:15-22
Owley, T; McMahon, W; Cook, E H et al. (2001) Multisite, double-blind, placebo-controlled trial of porcine secretin in autism. J Am Acad Child Adolesc Psychiatry 40:1293-9