Abstract

The overall goal of this project is to test both what is familial and what is specific about the idiopathic autism phenotype (IAP) at two levels of analysis: the symptom and neuropsychological levels. Previous research has identified social and/or language abnormalities in non-autistic first- degree relatives of probands with autism, which is referred to her as the Familial Autism Phenotype (FAP). This Project builds on that previous work and will specify in more detail the nature of the language abnormality in the FAP. However, neither the full range of symptoms nor all the underlying neuropsychological deficits founds in the IAP have been tested in non-autistic relatives, so that both the boundaries of the FAP and its similarity to the IAP remain unclear. It is also unclear which aspects of the FAP and the IAP are specific to autism and not found in other, even closely related developmental disabilities. This project will attempt to close these gaps in existing knowledge by comparing first degree relatives of autistic sib pairs with 1) first degree relatives of Down syndrome (DS) children, 2) females with fragile X syndrome (FXS) from Project III.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
3P01HD035468-02S1
Application #
6296827
Study Section
Project Start
1999-05-13
Project End
1999-05-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

McCormick, Carolyn; Hepburn, Susan; Young, Gregory S et al. (2016) Sensory symptoms in children with autism spectrum disorder, other developmental disorders and typical development: A longitudinal study. Autism 20:572-9
Hahn, Laura J; Fidler, Deborah J; Hepburn, Susan L et al. (2013) Early intersubjective skills and the understanding of intentionality in young children with Down syndrome. Res Dev Disabil 34:4455-65
Yerys, Benjamin E; Wolff, Brian C; Moody, Eric et al. (2012) Brief Report: impaired Flexible Item Selection Task (FIST) in school-age children with autism spectrum disorders. J Autism Dev Disord 42:2013-20
Lickel, Athena; MacLean Jr, William E; Blakeley-Smith, Audrey et al. (2012) Assessment of the prerequisite skills for cognitive behavioral therapy in children with and without autism spectrum disorders. J Autism Dev Disord 42:992-1000
Soke, Gnakub Norbert; Philofsky, Amy; Diguiseppi, Carolyn et al. (2011) Longitudinal changes in Scores on the Autism Diagnostic Interview--Revised (ADI-R) in pre-school children with autism: Implications for diagnostic classification and symptom stability. Autism 15:545-62
Rojas, Donald C; Maharajh, Keeran; Teale, Peter et al. (2008) Reduced neural synchronization of gamma-band MEG oscillations in first-degree relatives of children with autism. BMC Psychiatry 8:66
Roeder, Megan B; Mahone, E Mark; Gidley Larson, J et al. (2008) Left-right differences on timed motor examination in children. Child Neuropsychol 14:249-62
Wilson, Tony W; Rojas, Donald C; Reite, Martin L et al. (2007) Children and adolescents with autism exhibit reduced MEG steady-state gamma responses. Biol Psychiatry 62:192-7
Larson, Jennifer C Gidley; Mostofsky, Stewart H; Goldberg, Melissa C et al. (2007) Effects of gender and age on motor exam in typically developing children. Dev Neuropsychol 32:543-62
Scambler, D J; Hepburn, S; Rutherford, M D et al. (2007) Emotional responsivity in children with autism, children with other developmental disabilities, and children with typical development. J Autism Dev Disord 37:553-63

Showing the most recent 10 out of 27 publications