Vector CoreThe Vector Core at the University of Pennsylvania is an independent and full service laboratory providingreagents and expertise in the area of gene transfer. This facility called 'Penn Vector' is directed by Dr. JulieJohnston who manages 7 scientists in the area of AAV, adenovirus and lentiviral production. This programwill focus on utilization of Penn vector for the production of AAV vectors that will service Projects I through IIIAn independent Quality Control Program directed by Dr. Martin Lock performs a series of assays necessaryfor release of the vector for in vivo studies. This core will also analyze tissues for presence of vectorgenomes using TaqMan and PCR technology. Finally, the Vector Core will adapt existing methods ofmanufacturing and purification to the clinical candidate for a large scale production efficient enough tosupport large animals in a Phase 1 study. Assays necessary to support the ultimate clinical production willalso be developed. The laboratory operates under the general principles of GLP including, documentation(batch record forms), SOPs, QA/QC, training and equipment validation, although it does not represent itselfas being fully GLP or GMP.Lay description. All vectors used in the P01 will be. created and produced by the Vector Core.
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