The objective of this Program Project Application is the application of positron emission tomography for the in vivo assessment of metabolic pathways in various organs, specifically the brain, heart and lung. The approach is to develop methods for the in vivo regional measurement of physiological parameters and to extend this knowledge to the understanding of basic biological processes in normal and diseased states. Compounds are labeled with the positron emitting radionuclides oxygen-15, carbon-11 and fluorine-18, produced by the cyclotrons located in the Washington University Medical Center. These radionuclides are then combined into radiopharmaceuticals which can either measure flow, metabolism or other physiological and pharmacological parameters. These radiopharmaceuticals are administered to animals or human subjects and used to measure in vivo function. The metabolic images obtained using PET are correlated with anatomical images obtained using magnetic resonance imaging. The Program Project Grant Application includes four research projects in distinct areas all of which utilize positron tomography. The three areas are: a) synthesis and evaluation of new radiopharmaceuticals, b) neurological studies, c) cardiovascular studies; and d) pulmonary. Synergism exists between the three projects: they all share the 3 Core functions; they are all aimed at measuring metabolism and other physiological parameters in humans and image manipulation is important in all projects. The 4 Projects share the 3 Cores which provide administration, radionuclides, radiopharmaceuticals and state-of-the-art imaging devices. The Departments involved in this Program Project includes the Department of Radiology, the Department of Internal Medicine, the Department of Neurology and Neurosurgery and the Institute of Biomedical Computing.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Schools of Medicine
Saint Louis
United States
Zip Code
Peterson, Linda R; Herrero, Pilar; Coggan, Andrew R et al. (2015) Type 2 diabetes, obesity, and sex difference affect the fate of glucose in the human heart. Am J Physiol Heart Circ Physiol 308:H1510-6
Zhou, Dong; Chu, Wenhua; Xu, Jinbin et al. (2014) Synthesis, [¹?F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. Bioorg Med Chem 22:1700-7
Gropler, Robert J (2014) Trying to prevent diabetic cardiovascular autonomic neuropathy: more questions than answers. J Nucl Cardiol 21:842-4
Lyons, Matthew R; Peterson, Linda R; McGill, Janet B et al. (2013) Impact of sex on the heart's metabolic and functional responses to diabetic therapies. Am J Physiol Heart Circ Physiol 305:H1584-91
Herrero, Pilar; Laforest, Richard; Shoghi, Kooresh et al. (2012) Feasibility and dosimetry studies for 18F-NOS as a potential PET radiopharmaceutical for inducible nitric oxide synthase in humans. J Nucl Med 53:994-1001
Gropler, Robert J (2012) The road connecting obesity and coronary vasomotor function: straight line or U-turn? JACC Cardiovasc Imaging 5:816-8
Solingapuram Sai, Kiran Kumar; Kil, Kun-Eek; Tu, Zhude et al. (2012) Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-? receptors. Bioorg Med Chem Lett 22:6233-6
Cheng, Ju-Chieh Kevin; Shoghi, Kooresh; Laforest, Richard (2012) Quantitative accuracy of MAP reconstruction for dynamic PET imaging in small animals. Med Phys 39:1029-41
Peterson, Linda R; Saeed, Ibrahim M; McGill, Janet B et al. (2012) Sex and type 2 diabetes: obesity-independent effects on left ventricular substrate metabolism and relaxation in humans. Obesity (Silver Spring) 20:802-10
Zhou, Dong; Chu, Wenhua; Dence, Carmen S et al. (2012) Highly efficient click labeling using 2-[¹?F]fluoroethyl azide and synthesis of an ¹?FN-hydroxysuccinimide ester as conjugation agent. Nucl Med Biol 39:1175-81

Showing the most recent 10 out of 250 publications