Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG014600-08
Application #
6169536
Study Section
Neuropharmacology and Neurochemistry Review Committee (NPNC)
Program Officer
Snyder, D Stephen
Project Start
1992-06-01
Project End
2002-08-31
Budget Start
2000-09-01
Budget End
2002-08-31
Support Year
8
Fiscal Year
2000
Total Cost
$279,584
Indirect Cost

  Institution

Name
Winifred Masterson Burke Med Research Institute
Department
Type
DUNS #
780676131
City
White Plains
State
NY
Country
United States
Zip Code
10605

  Publications

Gibson, Gary E; Hirsch, Joseph A; Fonzetti, Pasquale et al. (2016) Vitamin B1 (thiamine) and dementia. Ann N Y Acad Sci 1367:21-30
Huang, Hsueh-Meei; Chen, Huan-Lian; Gibson, Gary E (2014) Interactions of endoplasmic reticulum and mitochondria Ca(2+) stores with capacitative calcium entry. Metab Brain Dis 29:1083-93
Bubber, P; Hartounian, V; Gibson, G E et al. (2011) Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients. Eur Neuropsychopharmacol 21:254-60
Gibson, Gary E; Starkov, Anatoly; Blass, John P et al. (2010) Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochim Biophys Acta 1802:122-34
Huang, Hsueh-Meei; Chen, Huan-Lian; Gibson, Gary E (2010) Thiamine and oxidants interact to modify cellular calcium stores. Neurochem Res 35:2107-16
Karuppagounder, Saravanan S; Xu, Hui; Shi, Qingli et al. (2009) Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiol Aging 30:1587-600
Shi, Qingli; Risa, Øystein; Sonnewald, Ursula et al. (2009) Mild reduction in the activity of the alpha-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis. J Neurochem 109 Suppl 1:214-21
Karuppagounder, Saravanan S; Pinto, John T; Xu, Hui et al. (2009) Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochem Int 54:111-8
Gibson, Gary E; Karuppagounder, Saravanan S; Shi, Qingli (2008) Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer's disease. Ann N Y Acad Sci 1147:221-32
Karuppagounder, Saravanan S; Xu, Hui; Pechman, David et al. (2008) Translocation of amyloid precursor protein C-terminal fragment(s) to the nucleus precedes neuronal death due to thiamine deficiency-induced mild impairment of oxidative metabolism. Neurochem Res 33:1365-72

Showing the most recent 10 out of 56 publications