Abstract

Function: This core provides a range of services that are essential to the success of the overall program: * In vivo studies of pulmonary and systematic circulation. * Operation of hypo- and hyperbaric chambers. * Coordination of management of animals in large animal hypobaric chambers at Colorado State University in Fort Collins, CO. * Maintenance of breeding colonies for inbred mice. * Preparation and renewal of animal Services. Provided: In vivo studies of pulmonary and systematic circulation: The Animal Core provides a vital bridge linking in vitro studies in isolated organs and vessels and cultured cells to the in vivo setting. This permits the important test of relevance of concepts developed in reduced preparations to intact animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL014985-34
Application #
7198044
Study Section
Project Start
Project End
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
34
Fiscal Year
2006
Total Cost
$82,936
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Graham, Brian B; Kumar, Rahul; Mickael, Claudia et al. (2018) Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension. Am J Respir Cell Mol Biol 59:479-489
Wick, Marilee J; Harral, Julie W; Loomis, Zoe L et al. (2018) An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse. J Vis Exp :
Reisz, Julie A; Barrett, Alexander S; Nemkov, Travis et al. (2018) When nature's robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies. Expert Rev Proteomics 15:293-309
Friesen, Richard M; Schäfer, Michal; Ivy, D Dunbar et al. (2018) Proximal pulmonary vascular stiffness as a prognostic factor in children with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging :
Stenmark, Kurt R; Tuder, Rubin M (2018) Peroxisome Proliferator-activated Receptor ? and Mitochondria: Drivers or Passengers on the Road to Pulmonary Hypertension? Am J Respir Cell Mol Biol 58:555-557
Jiang, Xinguo; Tian, Wen; Tu, Allen B et al. (2018) Endothelial HIF-2? is Required for the Maintenance of Airway Microvasculature. Circulation :
Das, Mita; Zawada, W Michael; West, James et al. (2018) JNK2 regulates vascular remodeling in pulmonary hypertension. Pulm Circ 8:2045894018778156
Tamosiuniene, Rasa; Manouvakhova, Olga; Mesange, Paul et al. (2018) Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension. Circ Res 122:1689-1702
Blum, Lisa K; Cao, Richard R L; Sweatt, Andrew J et al. (2018) Circulating plasmablasts are elevated and produce pathogenic anti-endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension. Eur J Immunol 48:874-884
Kumar, Rahul; Graham, Brian (2018) IL-33-HIF1? Axis in Hypoxic Pulmonary Hypertension. EBioMedicine 33:8-9

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