Abstract

Function: This core provides a range of services that are essential to the success of the overall program: * In vivo studies of pulmonary and systematic circulation. * Operation of hypo- and hyperbaric chambers. * Coordination of management of animals in large animal hypobaric chambers at Colorado State University in Fort Collins, CO. * Maintenance of breeding colonies for inbred mice. * Preparation and renewal of animal Services. Provided: In vivo studies of pulmonary and systematic circulation: The Animal Core provides a vital bridge linking in vitro studies in isolated organs and vessels and cultured cells to the in vivo setting. This permits the important test of relevance of concepts developed in reduced preparations to intact animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL014985-34
Application #
7198044
Study Section
Project Start
Project End
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
34
Fiscal Year
2006
Total Cost
$82,936
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Blum, Lisa K; Cao, Richard R L; Sweatt, Andrew J et al. (2018) Circulating plasmablasts are elevated and produce pathogenic anti-endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension. Eur J Immunol 48:874-884
Kumar, Rahul; Graham, Brian (2018) IL-33-HIF1? Axis in Hypoxic Pulmonary Hypertension. EBioMedicine 33:8-9
Ding, Yonghui; Xu, Xin; Sharma, Sadhana et al. (2018) Biomimetic soft fibrous hydrogels for contractile and pharmacologically responsive smooth muscle. Acta Biomater 74:121-130
Kumar, Rahul; Graham, Brian (2018) How does inflammation contribute to pulmonary hypertension? Eur Respir J 51:
Jiang, Xinguo; Nicolls, Mark R; Tian, Wen et al. (2018) Lymphatic Dysfunction, Leukotrienes, and Lymphedema. Annu Rev Physiol 80:49-70
Schäfer, Michal; Humphries, Stephen; Stenmark, Kurt R et al. (2018) 4D-flow cardiac magnetic resonance-derived vorticity is sensitive marker of left ventricular diastolic dysfunction in patients with mild-to-moderate chronic obstructive pulmonary disease. Eur Heart J Cardiovasc Imaging 19:415-424
D'Alessandro, Angelo; El Kasmi, Karim C; Plecitá-Hlavatá, Lydie et al. (2018) Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming. Antioxid Redox Signal 28:230-250
Karoor, Vijaya; Fini, Mehdi A; Loomis, Zoe et al. (2018) Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice. Arterioscler Thromb Vasc Biol 38:154-163
Stenmark, Kurt R; Graham, Brian B (2018) Urocortin 2: will a drug targeting both the vasculature and the right ventricle be the future of pulmonary hypertension therapy? Cardiovasc Res 114:1057-1059
Madhavan, Krishna; Frid, Maria G; Hunter, Kendall et al. (2018) Development of an electrospun biomimetic polyurea scaffold suitable for vascular grafting. J Biomed Mater Res B Appl Biomater 106:278-290

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