Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL047660-09
Application #
6353061
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
9
Fiscal Year
2000
Total Cost
$266,056
Indirect Cost
Name
J. David Gladstone Institutes
Department
Type
DUNS #
047120084
City
San Francisco
State
CA
Country
United States
Zip Code
94158
Zhang, Songwen; Picard, Michael H; Vasile, Eliza et al. (2005) Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Circulation 111:3457-64
Raffai, Robert L; Loeb, Samuel M; Weisgraber, Karl H (2005) Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels. Arterioscler Thromb Vasc Biol 25:436-41
Huang, Yadong; Weisgraber, Karl H; Mucke, Lennart et al. (2004) Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. J Mol Neurosci 23:189-204
Raffai, Robert L; Hasty, Alyssa H; Wang, Yuwei et al. (2003) Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance. J Biol Chem 278:11670-5
Hersberger, Martin; Patarroyo-White, Susannah; Qian, Xiaobing et al. (2003) Regulatable liver expression of the rabbit apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1 (APOBEC-1) in mice lacking endogenous APOBEC-1 leads to aberrant hyperediting. Biochem J 369:255-62
Aiyagari, Abigail L; Taylor, Brigit R; Aurora, Vikas et al. (2003) Hematologic effects of inactivating the Ras processing enzyme Rce1. Blood 101:2250-2
Raffai, Robert L; Weisgraber, Karl H (2002) Hypomorphic apolipoprotein E mice: a new model of conditional gene repair to examine apolipoprotein E-mediated metabolism. J Biol Chem 277:11064-8
Ludwig, Erwin H; Mahley, R W; Palaoglu, E et al. (2002) DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women. Clin Genet 62:68-73
Ji, Zhong-Sheng; Miranda, R Dennis; Newhouse, Yvonne M et al. (2002) Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells. J Biol Chem 277:21821-8
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