Abstract

a separate office for the P.I. and an 80 sq, ft.microscope room: There is a Cytovisionmachine, tissue culture facilities, analytical microscopesand molecular biology equipment::E. RELATION OF CORE UNITS TO RESEARCH PROJECTSCore B will provide services to Projects 1,2 3 and Core C. This is reviewed in the Introduction,p. 97. Breakage analysis is a critical aspect of the program. All Projects require breakageanalysis and FISH. Core C's ability to karyotype murine samples is a critical requirement ofProjects 1 and 2.A projected utilization of Core B by Projects on an annual basis is:Project 1-- 250 samples--evaluation of siRNA depletions, analysis of BLM cells, SCE'sProject 2-- 200 samples--evaluation of therapeutic interventionsProject 3-- 100 samples--human cell lines, response to cytokinesCore C-. 50 samples--complementation typingProject 2 will utilize FiSH significantly more than the other projects. Allanalysis and karyotype. : :Literature Citedof Fanconi anemia, Genet 15:211-2231. Cervenka J, Hirsch BA. Cytogenetic differentiationanemia and Fanconi anemia heterozygotes. Amer J Med2. Auerbach AD, Adler B, Chaganti RSK Prenatal andof Fanconi anemia by a cytogenetic method. Pediatrics259 postnatal diagnosis67: t 28-135 (1981)will use breakage'ideopathic' aplastic (1983)and carrier detection

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL048546-15
Application #
7650188
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
15
Fiscal Year
2008
Total Cost
$271,230
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Whiteaker, Jeffrey R; Zhao, Lei; Ivey, Richard G et al. (2018) Targeted mass spectrometry enables robust quantification of FANCD2 mono-ubiquitination in response to DNA damage. DNA Repair (Amst) 65:47-53
Kroeger Jr, Paul T; Drummond, Bridgette E; Miceli, Rachel et al. (2017) The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development. Dev Biol 428:148-163
Rondinelli, Beatrice; Gogola, Ewa; Yücel, Hatice et al. (2017) EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation. Nat Cell Biol 19:1371-1378
Karras, Georgios I; Yi, Song; Sahni, Nidhi et al. (2017) HSP90 Shapes the Consequences of Human Genetic Variation. Cell 168:856-866.e12
Mouw, Kent W; Goldberg, Michael S; Konstantinopoulos, Panagiotis A et al. (2017) DNA Damage and Repair Biomarkers of Immunotherapy Response. Cancer Discov 7:675-693
Garbati, Michael R; Hays, Laura E; Rathbun, R Keaney et al. (2016) Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages. J Leukoc Biol 99:455-65
Zhang, Qing-Shuo; Tang, Weiliang; Deater, Matthew et al. (2016) Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice. Blood 128:2774-2784
Zhang, Haojian; Kozono, David E; O'Connor, Kevin W et al. (2016) TGF-? Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia. Cell Stem Cell 18:668-81
Zhang, Qing-Shuo; Benedetti, Eric; Deater, Matthew et al. (2015) Oxymetholone therapy of fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling. Stem Cell Reports 4:90-102
Lombardi, Anne J; Hoskins, Elizabeth E; Foglesong, Grant D et al. (2015) Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers. Clin Cancer Res 21:1962-72

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