Core - Molecular Morphology

Wert, Susan

Abstract

Molecular Morphology Core The Molecular Morphology Core will provide technical advice, equipment, and training to those investigators who need to perform experiments that rely on microscopic evaluation and morphometric analysis for the interpretation of their results. Expertise and training will be provided by core personnel in the following ares: (1) routine light and electron microscopy (2) immunohistochemistry (3) enzyme histochemistry (4) autoradiography (5) in situ hybridization histochemistry (6) morphometric analysis (7) photomicroscopy In addition, the Molecular Morphology Core will facilitate the acquisition, processing, and storage of experimental and control tissues, maintain standards and quality control for histochemical procedures, and assist in the development of new techniques as needed.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Program Projects (P01)
• Project #: 5P01HL051832-03
• Application #: 3737217
• Support Year: 3
• Fiscal Year: 1995

Institution

• Name: Cincinnati Children's Hospital Medical Center
• DUNS #: 071284913
• City: Cincinnati
• State: OH
• Country: United States
• Zip Code: 45229

Publications

Wert, Susan E; Whitsett, Jeffrey A; Nogee, Lawrence M (2009) Genetic disorders of surfactant dysfunction. Pediatr Dev Pathol 12:253-74

Zsengeller, Z K; Ross, G F; Trapnell, B C et al. (2001) Adenovirus infection increases iNOS and peroxynitrite production in the lung. Am J Physiol Lung Cell Mol Physiol 280:L503-11

Zeng, X; Gray, M; Stahlman, M T et al. (2001) TGF-beta1 perturbs vascular development and inhibits epithelial differentiation in fetal lung in vivo. Dev Dyn 221:289-301

Iwamoto, H S; Trapnell, B C; McConnell, C J et al. (1999) Pulmonary inflammation associated with repeated, prenatal exposure to an E1, E3-deleted adenoviral vector in sheep. Gene Ther 6:98-106

Zsengeller, Z K; Halbert, C; Miller, A D et al. (1999) Keratinocyte growth factor stimulates transduction of the respiratory epithelium by retroviral vectors. Hum Gene Ther 10:341-53

Schwarz, Y A; Amin, R S; Stark, J M et al. (1999) Interleukin-1 receptor antagonist inhibits interleukin-8 expression in A549 respiratory epithelial cells infected in vitro with a replication-deficient recombinant adenovirus vector. Am J Respir Cell Mol Biol 21:388-94

Otake, K; Ennist, D L; Harrod, K et al. (1998) Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses. Hum Gene Ther 9:2207-22

Jain-Vora, S; LeVine, A M; Chroneos, Z et al. (1998) Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa. Infect Immun 66:4229-36

Zeng, X; Wert, S E; Federici, R et al. (1998) VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo. Dev Dyn 211:215-27

Weaver, T E (1998) Synthesis, processing and secretion of surfactant proteins B and C. Biochim Biophys Acta 1408:173-9