Abstract

Specific Aims: The overall goal of this Core Unit is to coordinate the use of animals needed by investigators of each of the five projects of this Program Project. To accomplish this function, the Core will implement the following Specific Aims.
SPECIFIC AIM 1 is to maintain breeder colonies of (mRen2)27 transgenic (TG) hypertensive rats, the newly developed congenic mRen2.Lewis rats, angiotensinogen antisense transgenic [ASrAogen TG] rats, Hannover Sprague-Dawley (Hann SD) rats, and to establish a breeding colony of ACE2 knockout (ACE2 KO) mice.
SPECIFIC AIM 2 is to produce hemizygous (mRen2) TG and mRen2.Lewis rats, homozygous ASrAogen rats, Hannover SD rats, and ACE2 KO mice as appropriate to the scientific objectives in each of the five projects. In addition, the Core Unit will oversee the procurement of rats and mice from commercial vendors.
SPECIFIC AIM 3 will be to coordinate the housing provided by the Animal Resources Program (ARP) at the Wake Forest University School of Medicine for all animals used by investigators of this Program Project grant.
SPECIFIC AIM 4 will be to assist investigators in the preparation of animals for experiments proposed in this Program Project grant. In particular, Dr. Averill, as the Core Leader, will provide technical advice and assistance in the instrumentation of rats and mice for chronic measurement of arterial blood pressure and blood flow.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL051952-15
Application #
7586117
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
15
Fiscal Year
2008
Total Cost
$191,491
Indirect Cost

  Institution

Name
Wake Forest University Health Sciences
Department
Type
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157

  Publications

Dell'Italia, Louis J; Collawn, James F; Ferrario, Carlos M (2018) Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling. Circ Res 122:319-336
Ahmad, Sarfaraz; Ferrario, Carlos M (2018) Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010-2018). Expert Opin Ther Pat 28:755-764
Wang, Hao; Sun, Xuming; Lin, Marina S et al. (2018) G protein-coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress. Transl Res 199:39-51
Ahmad, Sarfaraz; Sun, Xuming; Lin, Marina et al. (2018) Blunting of estrogen modulation of cardiac cellular chymase/RAS activity and function in SHR. J Cell Physiol 233:3330-3342
Li, Tiankai; Zhang, Xiaowei; Cheng, Heng-Jie et al. (2018) Critical role of the chymase/angiotensin-(1-12) axis in modulating cardiomyocyte contractility. Int J Cardiol 264:137-144
Ola, Mohammad Shamsul; Alhomida, Abdullah S; Ferrario, Carlos M et al. (2017) Role of Tissue Renin-angiotensin System and the Chymase/angiotensin-( 1-12) Axis in the Pathogenesis of Diabetic Retinopathy. Curr Med Chem 24:3104-3114
Ferrario, Carlos M; Mullick, Adam E (2017) Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease. Pharmacol Res 125:57-71
Chappell, Mark C; Al Zayadneh, Ebaa M (2017) Angiotensin-(1-7) and the Regulation of Anti-Fibrotic Signaling Pathways. J Cell Signal 2:
Alencar, Allan K; da Silva, Jaqueline S; Lin, Marina et al. (2017) Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344×Brown Norway Female Rat. J Gerontol A Biol Sci Med Sci 72:152-162
Guichard, Jason L; Rogowski, Michael; Agnetti, Giulio et al. (2017) Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure. Am J Physiol Heart Circ Physiol 313:H32-H45

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