Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL054804-02
Application #
2233264
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
1995-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Oklahoma Medical Research Foundation
Department
Type
DUNS #
937727907
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104
van Sluis, G L; Bruggemann, L W; Esmon, C T et al. (2011) Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation. Cancer Lett 306:106-10
Srivastava, Arvind; Wang, Jianfang; Majumder, Rinku et al. (2002) Localization of phosphatidylserine binding sites to structural domains of factor Xa. J Biol Chem 277:1855-63
Liaw, P C; Mather, T; Oganesyan, N et al. (2001) Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor. J Biol Chem 276:8364-70
Faust, S N; Levin, M; Harrison, O B et al. (2001) Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N Engl J Med 345:408-16
Alberio, L; Lammle, B; Esmon, C T (2001) Protein C replacement in severe meningococcemia: rationale and clinical experience. Clin Infect Dis 32:1338-46
Xu, J; Qu, D; Esmon, N L et al. (2000) Metalloproteolytic release of endothelial cell protein C receptor. J Biol Chem 275:6038-44
Gu, J M; Katsuura, Y; Ferrell, G L et al. (2000) Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo. Blood 95:1687-93
Rezaie, A R; He, X (2000) Sodium binding site of factor Xa: role of sodium in the prothrombinase complex. Biochemistry 39:1817-25
Esmon, C T (2000) The anticoagulant and anti-inflammatory roles of the protein C anticoagulant pathway. J Autoimmun 15:113-6
Taylor Jr, F B; Stearns-Kurosawa, D J; Kurosawa, S et al. (2000) The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Blood 95:1680-6

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