Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL055552-03
Application #
6242585
Study Section
Project Start
1997-09-01
Project End
1998-08-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Solovey, Anna; Somani, Arif; Belcher, John D et al. (2017) A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade. Am J Hematol 92:1119-1130
Belcher, John D; Chen, Chunsheng; Nguyen, Julia et al. (2014) Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood 123:377-90
Shirodkar, Apurva V; St Bernard, Rosanne; Gavryushova, Anna et al. (2013) A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing. Blood 121:3531-40
Schaer, Dominik J; Buehler, Paul W; Alayash, Abdu I et al. (2013) Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood 121:1276-84
Nath, Karl A; Grande, Joseph P; Farrugia, Gianrico et al. (2013) Age sensitizes the kidney to heme protein-induced acute kidney injury. Am J Physiol Renal Physiol 304:F317-25
Mulrooney, Daniel A; Ness, Kirsten K; Huang, Sujuan et al. (2013) Pilot study of vascular health in survivors of osteosarcoma. Pediatr Blood Cancer 60:1703-8
Weber, M L; Chen, C; Li, Y et al. (2013) Morphine stimulates platelet-derived growth factor receptor-? signalling in mesangial cells in vitro and transgenic sickle mouse kidney in vivo. Br J Anaesth 111:1004-12
Martin, Fernando L; McKie, Paul M; Cataliotti, Alessandro et al. (2012) Experimental mild renal insufficiency mediates early cardiac apoptosis, fibrosis, and diastolic dysfunction: a kidney-heart connection. Am J Physiol Regul Integr Comp Physiol 302:R292-9
Weber, Marc L; Vang, Derek; Velho, Paulo E et al. (2012) Morphine promotes renal pathology in sickle mice. Int J Nephrol Renovasc Dis 5:109-18
Mulrooney, Daniel A; Ness, Kirsten K; Solovey, Anna et al. (2012) Pilot study of vascular health in survivors of Hodgkin lymphoma. Pediatr Blood Cancer 59:285-9

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