Abstract

This Core C (Transgenic Mouse) will provide for breeding, characterization, and housing of multiple type of mice for subsequent distribution to individual projects for specific experiments. Core functions include rigorous analysis and quality control, with redundancy in animal identification to preclude errors. LAY SUMMARY: This core will create different kinds of mice for use in the program projects, each of which has important public health implications.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL055552-13
Application #
7919946
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
13
Fiscal Year
2009
Total Cost
$545,919
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Solovey, Anna; Somani, Arif; Belcher, John D et al. (2017) A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade. Am J Hematol 92:1119-1130
Belcher, John D; Chen, Chunsheng; Nguyen, Julia et al. (2014) Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood 123:377-90
Shirodkar, Apurva V; St Bernard, Rosanne; Gavryushova, Anna et al. (2013) A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing. Blood 121:3531-40
Schaer, Dominik J; Buehler, Paul W; Alayash, Abdu I et al. (2013) Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood 121:1276-84
Nath, Karl A; Grande, Joseph P; Farrugia, Gianrico et al. (2013) Age sensitizes the kidney to heme protein-induced acute kidney injury. Am J Physiol Renal Physiol 304:F317-25
Mulrooney, Daniel A; Ness, Kirsten K; Huang, Sujuan et al. (2013) Pilot study of vascular health in survivors of osteosarcoma. Pediatr Blood Cancer 60:1703-8
Weber, M L; Chen, C; Li, Y et al. (2013) Morphine stimulates platelet-derived growth factor receptor-? signalling in mesangial cells in vitro and transgenic sickle mouse kidney in vivo. Br J Anaesth 111:1004-12
Mulrooney, Daniel A; Ness, Kirsten K; Solovey, Anna et al. (2012) Pilot study of vascular health in survivors of Hodgkin lymphoma. Pediatr Blood Cancer 59:285-9
Manning, Benjamin M; Hebbel, Robert P; Gupta, Kalpna et al. (2012) Carbon-fiber microelectrode amperometry reveals sickle-cell-induced inflammation and chronic morphine effects on single mast cells. ACS Chem Biol 7:543-51
Vercellotti, Gregory M; Moldow, Charles F; Jacob, Harry S (2012) Complement, oxidants, and endothelial injury: how a bedside observation opened a door to vascular biology. J Clin Invest 122:3044-5

Showing the most recent 10 out of 107 publications