Abstract

The Objectives of the Biostatistics Core activities are: 1. To maintain and implement where necessary, a comprehensive, high quality system of data entry, data management, quality control, and data security strategies for each of the four Projects and Cores A and C. II. To create data analysis plans using Project results and the data from the DCCT/EDIC Research Group and the VA Cooperative Studies trial. These activities involve analyses that examine the association of baseline measures from both of these studies and the molecular parameters being measured within each of the 4 Projects and Core C. III. To create data analysis plans using Project results and the data from the DCCT/EDIC Research Group and the VA Cooperative Study. These activities involve analyses that examine the development of macrovascular disease endpoints within the two study cohorts together with molecular parameters being measured within each of the 4 Projects and Core C. IV. To facilitate the statistical analysis plans of each Project and assist the investigators in using the results from all analyses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL055782-06
Application #
6495742
Study Section
Project Start
1996-09-30
Project End
2006-08-31
Budget Start
Budget End
Support Year
6
Fiscal Year
2001
Total Cost
$73,467
Indirect Cost

  Institution

Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425

  Publications

Hunt, Kelly J; Jaffa, Miran A; Garrett, Sara M et al. (2018) Plasma Connective Tissue Growth Factor (CTGF/CCN2) Levels Predict Myocardial Infarction in the Veterans Affairs Diabetes Trial (VADT) Cohort. Diabetes Care 41:840-846
Jaffa, Miran A; Gebregziabher, Mulugeta; Garrett, Sara M et al. (2018) Analysis of longitudinal semicontinuous data using marginalized two-part model. J Transl Med 16:301
Hammad, Samar M; Baker, Nathaniel L; El Abiad, Jad M et al. (2017) Increased Plasma Levels of Select Deoxy-ceramide and Ceramide Species are Associated with Increased Odds of Diabetic Neuropathy in Type 1 Diabetes: A Pilot Study. Neuromolecular Med 19:46-56
Jaffa, Miran A; Luttrell, Deirdre; Schmaier, Alvin H et al. (2016) Plasma Prekallikrein Is Associated With Carotid Intima-Media Thickness in Type 1 Diabetes. Diabetes 65:498-502
Jaffa, Miran A; Gebregziabher, Mulugeta; Luttrell, Deirdre K et al. (2016) Multivariate Generalized Linear Mixed Models With Random Intercepts To Analyze Cardiovascular Risk Markers in Type-1 Diabetic Patients. J Appl Stat 43:1447-1464
Jaffa, Miran A; Lipsitz, Stuart; Woolson, Robert F (2015) Slope estimation for informatively right censored longitudinal data modelling the number of observations using geometric and Poisson distributions: application to renal transplant cohort. Stat Methods Med Res 24:819-35
Hunt, Kelly J; Baker, Nathaniel L; Cleary, Patricia A et al. (2015) Longitudinal Association Between Endothelial Dysfunction, Inflammation, and Clotting Biomarkers With Subclinical Atherosclerosis in Type 1 Diabetes: An Evaluation of the DCCT/EDIC Cohort. Diabetes Care 38:1281-9
Thalacker-Mercer, Anna E; Ingram, Katherine H; Guo, Fangjian et al. (2014) BMI, RQ, diabetes, and sex affect the relationships between amino acids and clamp measures of insulin action in humans. Diabetes 63:791-800
Klein, Richard L; Hammad, Samar M; Baker, Nathaniel L et al. (2014) Decreased plasma levels of select very long chain ceramide species are associated with the development of nephropathy in type 1 diabetes. Metabolism 63:1287-95
Basu, Arpita; Jenkins, Alicia J; Stoner, Julie A et al. (2014) Plasma total homocysteine and carotid intima-media thickness in type 1 diabetes: a prospective study. Atherosclerosis 236:188-195

Showing the most recent 10 out of 119 publications