Abstract

This Core is designed to support all of the four projects in the Program Project for work on gene expression and proteomics. We combined the Proteomics and Genomics Core under one umbrella, because each part of the Core will need the other in terms of determining whether gene expression is accompanied by protein expression and vice versa. It also conserves costs, since the technical help at the Newark campus can be shared. This Core supports all the Projects with the following distribution: Project 1""""""""40%; Project 2: 30%; Project 3: 10%; Project 4: 20%. The tissues used by the Core will be provided by the individual projects and Core B. Therefore, the function of this Core does not involve tissue harvesting and processing.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL059139-10
Application #
7391226
Study Section
Project Start
2007-03-01
Project End
2008-02-29
Budget Start
2007-03-01
Budget End
2008-02-29
Support Year
10
Fiscal Year
2007
Total Cost
$478,966
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Type
DUNS #
623946217
City
Newark
State
NJ
Country
United States
Zip Code
07107

  Publications

Yamamoto, Takanobu; Byun, Jaemin; Zhai, Peiyong et al. (2014) Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PLoS One 9:e98972
Del Re, Dominic P; Yang, Yanfei; Nakano, Noritsugu et al. (2013) Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J Biol Chem 288:3977-88
Matsushima, Shouji; Kuroda, Junya; Ago, Tetsuro et al. (2013) Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1? and upregulation of peroxisome proliferator-activated receptor-?. Circ Res 112:1135-49
Zablocki, Daniela; Sadoshima, Junichi (2013) Angiotensin II and oxidative stress in the failing heart. Antioxid Redox Signal 19:1095-109
Hariharan, Nirmala; Ikeda, Yoshiyuki; Hong, Chull et al. (2013) Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart. PLoS One 8:e51632
Zschauer, Tim-Christian; Matsushima, Shouji; Altschmied, Joachim et al. (2013) Interacting with thioredoxin-1--disease or no disease? Antioxid Redox Signal 18:1053-62
Maejima, Yasuhiro; Kyoi, Shiori; Zhai, Peiyong et al. (2013) Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med 19:1478-88
Del Re, Dominic P; Sadoshima, Junichi (2012) Enhancing the potential of cardiac progenitor cells: pushing forward with Pim-1. Circ Res 110:1154-6
Herman, Daniel S; Lam, Lien; Taylor, Matthew R G et al. (2012) Truncations of titin causing dilated cardiomyopathy. N Engl J Med 366:619-28
Sciarretta, Sebastiano; Zhai, Peiyong; Shao, Dan et al. (2012) Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation 125:1134-46

Showing the most recent 10 out of 192 publications