Abstract

The primary purposes of this core are as follows: 1. To provide animal models with uniform methods and to minimize unexpected morbidity and mortality for each of the projects 2. To provide continued large animal care and data collection for chronic studies. 3. To provide gross and histopathological evaluation of tissues derived from experimental animal studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL067961-02
Application #
6630625
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2002-08-01
Project End
2003-07-31
Budget Start
2002-08-01
Budget End
2003-07-31
Support Year
2
Fiscal Year
2002
Total Cost
$164,585
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Walcott, Gregory P; Melnick, Sharon B; Killingsworth, Cheryl R et al. (2010) Comparison of low-energy versus high-energy biphasic defibrillation shocks following prolonged ventricular fibrillation. Prehosp Emerg Care 14:62-70
Walcott, Gregory; Melnick, Sharon; Killingsworth, Cheryl et al. (2009) Burst stimulation improves hemodynamics during resuscitation after prolonged ventricular fibrillation. Circ Arrhythm Electrophysiol 2:57-62
Doppalapudi, Harish; Jin, Qi; Dosdall, Derek J et al. (2008) Intracoronary infusion of catecholamines causes focal arrhythmias in pigs. J Cardiovasc Electrophysiol 19:963-70
Dosdall, Derek J; Cheng, Kang-An; Huang, Jian et al. (2007) Transmural and endocardial Purkinje activation in pigs before local myocardial activation after defibrillation shocks. Heart Rhythm 4:758-65
Dosdall, Derek J; Ideker, Raymond E (2007) Intracardiac atrial defibrillation. Heart Rhythm 4:S51-6
Kong, Wei; Huang, Jian; Rollins, Dennis L et al. (2007) A semi-implantable multichannel telemetry system for continuous electrical, mechanical and hemodynamical recordings in animal cardiac research. Physiol Meas 28:249-57
Lan, David Z; Pollard, Andrew E; Knisley, Stephen B et al. (2007) Optical mapping of V(m) and Ca(i)(2+) in a model of arrhythmias induced by local catecholamine application in patterned cell cultures. Pflugers Arch 453:871-7
Raman, Vidya; Pollard, Andrew E; Fast, Vladimir G (2007) Shock-induced changes of Ca(i)2+ and Vm in myocyte cultures and computer model: Dependence on the timing of shock application. Cardiovasc Res 73:101-10
Killingsworth, Cheryl R; Walcott, Gregory P; Gamblin, Tracy L et al. (2006) Chronic myocardial infarction is a substrate for bradycardia-induced spontaneous tachyarrhythmias and sudden death in conscious animals. J Cardiovasc Electrophysiol 17:189-97
Ideker, Raymond E; Rogers, Jack M (2006) Human ventricular fibrillation: wandering wavelets, mother rotors, or both? Circulation 114:530-2

Showing the most recent 10 out of 35 publications