Abstract

The investigators participating in this Program Project Grant are united by interests in the cellular mechanisms underlying the heart.s response to ischemia-reperfusion. The Cell Culture Core Unit will promote the objectives of the research program by providing isolated cardiac myocytes and fibroblasts required by each Project for investigation of G protein-coupled receptor regulation, intracellular signaling, and mitochondrial function. This Core will also performed specific experimentation for each Project and house the equipment and technical expertise required for in vitro studies of hypoxia-reoxygenation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL068738-01A1
Application #
6652380
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
2002-08-01
Project End
2007-07-31
Budget Start
2002-08-01
Budget End
2003-07-31
Support Year
1
Fiscal Year
2002
Total Cost
$308,662
Indirect Cost

  Institution

Name
Northern California Institute Research & Education
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94121

  Publications

Karliner, Joel S (2013) Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress. Biochim Biophys Acta 1831:203-12
Kawabori, Masahito; Kacimi, Rachid; Karliner, Joel S et al. (2013) Sphingolipids in cardiovascular and cerebrovascular systems: Pathological implications and potential therapeutic targets. World J Cardiol 5:75-86
Lovett, David H; Mahimkar, Rajeev; Raffai, Robert L et al. (2013) N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. PLoS One 8:e68154
Lovett, David H; Mahimkar, Rajeev; Raffai, Robert L et al. (2012) A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity. PLoS One 7:e34177
Dahi, Sia; Karliner, Joel S; Sarkar, Rajabrata et al. (2011) Transgenic expression of matrix metalloproteinase-2 induces coronary artery ectasia. Int J Exp Pathol 92:50-6
Vessey, Donald A; Li, Luyi; Jin, Zhu-Qiu et al. (2011) A sphingosine kinase form 2 knockout sensitizes mouse myocardium to ischemia/reoxygenation injury and diminishes responsiveness to ischemic preconditioning. Oxid Med Cell Longev 2011:961059
Kotlyar, Alexander B; Randazzo, Antonio; Honbo, Norman et al. (2010) Cardioprotective activity of a novel and potent competitive inhibitor of lactate dehydrogenase. FEBS Lett 584:159-65
Wang, Guan-Ying; Yeh, Che-Chung; Jensen, Brian C et al. (2010) Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive. Am J Physiol Heart Circ Physiol 298:H913-20
Chatterjee, Kanu; Zhang, Jianqing; Honbo, Norman et al. (2010) Doxorubicin cardiomyopathy. Cardiology 115:155-62
Tao, Rong; Hoover, Holly E; Honbo, Norman et al. (2010) High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate. Am J Physiol Heart Circ Physiol 298:H1022-8

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