Pulmonary infections are frequent complications of HIV infection and a common cause of death in patients with AIDS. Pulmonary pathogens complicating HIV infection include bacteria (pneumonia), fungi (Pneumocystis carinii), and mycobacteria (tuberculosis). Antimicrobial therapy is possible for many of these infections, but such therapies may not be available in developing countries and antibiotic resistance is an increasing problem. A more direct solution to the problem of HIV-related pulmonary infections is to correct the defects in host defense caused by HIV infection. The long-term objective of this Project is to identify new methods to augment host defense against pulmonary infection in HIV-infected patients. In this application, we will direct and coordinate a group of established investigators in host defense to conduct research targeted to HIV-related pulmonary infections. The Project theme is to explore genetic approaches to enhance the delivery of immune effector cells into lung tissue in order to augment clearance of HIV-related pulmonary infections. We postulate that genetic approaches can be used to either increase local signals for recruitment of immune effector cells into infected lung tissue or to increase the pool of circulating effector cells available for recruitment. Four interactive research projects will address: 1. CXCR3 ligands as signals for lymphocyte recruitment in host defense against P. carinii (Dr. Shellito) 2. CD4-independent vaccine strategies for pulmonary infections (Dr. Kolls) 3. Prime/boost vaccination strategies for pulmonary tuberculosis (Drs. Ramsay, Mason) 4. Strategies to increase hematopoietic responses to bacterial pneumonia (Drs. Schwarzenberger, Nelson, and Bagby) The research projects will be supported by 3 core components: Administrative Core (Dr. Shellito), Immunology Core (Dr. Zhang), Vector Core (Dr. Reiser) Project research will develop and validate new methods of immune augmentation in animal models of pulmonary infection relevant to HIV infection. Data generated will then provide a foundation for future applications to HIV-infected patients.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL076100-01
Application #
6705097
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Program Officer
Peavy, Hannah H
Project Start
2004-02-10
Project End
2009-01-31
Budget Start
2004-02-10
Budget End
2005-01-31
Support Year
1
Fiscal Year
2004
Total Cost
$1,543,865
Indirect Cost
Name
Louisiana State University Hsc New Orleans
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Samuelson, Derrick R; Burnham, Ellen L; Maffei, Vincent J et al. (2018) The respiratory tract microbial biogeography in alcohol use disorder. Am J Physiol Lung Cell Mol Physiol 314:L107-L117
Maffei, Vincent J; Kim, Sangkyu; Blanchard 4th, Eugene et al. (2017) Biological Aging and the Human Gut Microbiota. J Gerontol A Biol Sci Med Sci 72:1474-1482
Byerley, Lauri O; Samuelson, Derrick; Blanchard 4th, Eugene et al. (2017) Changes in the gut microbial communities following addition of walnuts to the diet. J Nutr Biochem 48:94-102
Samuelson, Derrick R; Shellito, Judd E; Maffei, Vincent J et al. (2017) Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae. PLoS Pathog 13:e1006426
Goldsmith, Felicia; Guice, Justin; Page, Ryan et al. (2017) Obese ZDF rats fermented resistant starch with effects on gut microbiota but no reduction in abdominal fat. Mol Nutr Food Res 61:
Ruan, Sanbao; Cai, Yang; Ramsay, Alistair J et al. (2017) B cell and antibody responses in mice induced by a putative cell surface peptidase of Pneumocystis murina protect against experimental infection. Vaccine 35:672-679
Bruce-Keller, Annadora J; Salbaum, J Michael; Luo, Meng et al. (2016) Reply to: High-Fat Diet-Induced Dysbiosis as a Cause of Neuroinflammation. Biol Psychiatry 80:e5-6
Kling, Heather M; Norris, Karen A (2016) Vaccine-Induced Immunogenicity and Protection Against Pneumocystis Pneumonia in a Nonhuman Primate Model of HIV and Pneumocystis Coinfection. J Infect Dis 213:1586-95
Dai, Guixiang; Rady, Hamada F; Huang, Weitao et al. (2016) Gene-based neonatal immune priming potentiates a mucosal adenoviral vaccine encoding mycobacterial Ag85B. Vaccine 34:6267-6275
de la Rua, Nicholas M; Samuelson, Derrick R; Charles, Tysheena P et al. (2016) CD4(+) T-Cell-Independent Secondary Immune Responses to Pneumocystis Pneumonia. Front Immunol 7:178

Showing the most recent 10 out of 49 publications