Building on 25 years of close collaboration between the Core Leader (Professor Maislin) and the Program Project Director (Dr. Allan Pack), and as long with many of the Program's investigators, collaborators, and consultants, the primary responsibilities of Core E will be to guarantee the application of good statistical and scientific practice in the conduct of every research protocol; to collaborate with investigators in the design and development of research protocols; to insure the implementation of the statistical analysis plans developed for the Projects; to develop new approaches to analysis and to adapt and adopt new approaches appearing in the literature that are relevant to the Specific Aims; and to ensure the fair, accurate, and unbiased publication of research findings. This Core will also manage the capture and storage of clinical data through the use of the REDCap system.

Public Health Relevance

The Biostatistics and Data Management Core has been supporting research at the Center for Sleep and Circadian Neurobiology under the leadership of Greg Maislin, Adjunct Professor of Statistics in Medicine since 1990. Members of the Core work collaboratively with faculty and investigators to ensure that proper and valid statistical methods are used in the analysis of data. The Core adapts existing methods or develops new methods as needed to address scientific challenges as they arise. Finally, the Core supports an integrated data management system that is secure, compliant with privacy regulations, and allows data to be captured, organized, and available for statistical analysis.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL094307-07
Application #
9335395
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Program Officer
Laposky, Aaron D
Project Start
Project End
Budget Start
2017-05-01
Budget End
2018-04-30
Support Year
7
Fiscal Year
2017
Total Cost
$233,138
Indirect Cost
$88,332
Name
University of Pennsylvania
Department
Type
Domestic Higher Education
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Feng, Yuan; Keenan, Brendan T; Wang, Stephen et al. (2018) Dynamic Upper Airway Imaging during Wakefulness in Obese Subjects with and without Sleep Apnea. Am J Respir Crit Care Med 198:1435-1443
Sands, Scott A; Edwards, Bradley A; Terrill, Philip I et al. (2018) Phenotyping Pharyngeal Pathophysiology using Polysomnography in Patients with Obstructive Sleep Apnea. Am J Respir Crit Care Med 197:1187-1197
Pien, Grace W; Ye, Lichuan; Keenan, Brendan T et al. (2018) Changing Faces of Obstructive Sleep Apnea: Treatment Effects by Cluster Designation in the Icelandic Sleep Apnea Cohort. Sleep 41:
Mazzotti, Diego R; Lim, Diane C; Sutherland, Kate et al. (2018) Opportunities for utilizing polysomnography signals to characterize obstructive sleep apnea subtypes and severity. Physiol Meas 39:09TR01
Sands, Scott A; Edwards, Bradley A; Terrill, Philip I et al. (2018) Identifying obstructive sleep apnoea patients responsive to supplemental oxygen therapy. Eur Respir J 52:
Keenan, Brendan T; Kim, Jinyoung; Singh, Bhajan et al. (2018) Recognizable clinical subtypes of obstructive sleep apnea across international sleep centers: a cluster analysis. Sleep 41:
van Hees, Vincent Theodoor; Sabia, S; Jones, S E et al. (2018) Estimating sleep parameters using an accelerometer without sleep diary. Sci Rep 8:12975
Shulman, Rachel; Cohen, Debbie L; Grandner, Michael A et al. (2018) Sleep duration and 24-hour ambulatory blood pressure in adults not on antihypertensive medications. J Clin Hypertens (Greenwich) 20:1712-1720
Gao, Xiaoling; Azarbarzin, Ali; Keenan, Brendan T et al. (2017) Heritability of Heart Rate Response to Arousals in Twins. Sleep 40:
Lyons, M Melanie; Keenan, Brendan T; Li, Junxin et al. (2017) Symptomless Multi-Variable Apnea Prediction Index Assesses Obstructive Sleep Apnea Risk and Adverse Outcomes in Elective Surgery. Sleep 40:

Showing the most recent 10 out of 51 publications