Abstract

The Program Project will unite established investigators in an intensive program of research exploring the interrelationships of thyroid axis hormones, brain and behavior, with the specific goal of better understanding the role played by this interaction in the genesis, expression and treatment of affective illness, particularly bipolar disorder. Four interrelated projects are proposed exploring various aspects of thyroid physiology and genetics in normal human beings, those with manic depressive illness, and rapid cycling bipolar disorder; in animals, the possible physiological and pharmacological underpinnings of the association are investigated through circadian models, photoperiod challenge, and the study of those psychotropic agents usually employed in the management of bipolar disease: Project I (P.C. Whybrow, MD, PI) - Thyroid Hormones and Affective Illness: Clinical Studies Project II (R.C. Gur, PhD, PI) - Thyroid Function, Affective Disturbance and Regional Cerebral Blood Flow Project III (R.A. Price, PhD, PI) - Genetic Family Study of Thyroid Function in Rapid Cycling Disease Project IV (M.B. Dratman, MD, PI) - Psychopharmacology and Thyroid Hormone Processing in Brain These individual projects are coordinated and supported by two integrating cores that assure standard procedures: Core 1 (M.S. Kreider, PhD, PI) - Radioimmunoassay and Chemical Analyses Core 2 (L. Muenz, PhD, PI) - Data Management and Statistics

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program Projects (P01)
Project #
5P01MH044210-05
Application #
3099111
Study Section
Special Emphasis Panel (SRCM (19))
Project Start
1989-09-01
Project End
1994-08-31
Budget Start
1993-09-01
Budget End
1994-08-31
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Greenberg, Joel H; Reivich, Martin; Gordon, Janice T et al. (2006) Imaging triiodothyronine binding kinetics in rat brain: a model for studies in human subjects. Synapse 60:212-22
Gyulai, Laszlo; Bauer, Michael; Bauer, Mark S et al. (2003) Thyroid hypofunction in patients with rapid-cycling bipolar disorder after lithium challenge. Biol Psychiatry 53:899-905
Gyulai, L; Bauer, M; Garcia-Espana, F et al. (2001) Bone mineral density in pre-and post-menopausal women with affective disorder treated with long-term L-thyroxine augmentation. J Affect Disord 66:185-91
Hahn, C G; Pawlyk, A C; Whybrow, P C et al. (1999) Lithium administration affects gene expression of thyroid hormone receptors in rat brain. Life Sci 64:1793-802
Hahn, C G; Pawlyk, A C; Whybrow, P C et al. (1999) Differential expression of thyroid hormone receptor isoforms by thyroid hormone and lithium in rat GH3 and B103 cells. Biol Psychiatry 45:1004-12
Gyulai, L; Jaggi, J; Bauer, M S et al. (1997) Bone mineral density and L-thyroxine treatment in rapidly cycling bipolar disorder. Biol Psychiatry 41:503-6
Gyulai, L; Alavi, A; Broich, K et al. (1997) I-123 iofetamine single-photon computed emission tomography in rapid cycling bipolar disorder: a clinical study. Biol Psychiatry 41:152-61
Rozanov, C B; Dratman, M B (1996) Immunohistochemical mapping of brain triiodothyronine reveals prominent localization in central noradrenergic systems. Neuroscience 74:897-915
Gottschalk, A; Bauer, M S; Whybrow, P C (1995) Evidence of chaotic mood variation in bipolar disorder. Arch Gen Psychiatry 52:947-59
Gordon, J T; Tomlinson, E E; Greenberg, J et al. (1994) An acute dose of desmethylimipramine inhibits brain uptake of [125I]3,3',5-triiodothyronine (T3) in thyroxine-induced but not T3-induced hyperthyroid rats: implications for tricyclic antidepressant therapy. J Pharmacol Exp Ther 270:111-7

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