Abstract

I. The structure of the primary ending of the living mammalian muscle spindle would be studied using fluorescent dyes as well as Nomarksi images. Dimensional changes of the terminals will be examined at different spindle lengths. A 3-dimensional reconstruction would be made permitting a quantitative description of the geometry of the ending. A model of the spindle derived from these data will be useful in understanding the function of this important mechanoreceptor. Changes in geometry with suggest possible modes of transduction. II. Relation between motor axon conduction velocity and muscle fiber innervation. Deoxyglucose will be used to label muscle fibers in one of the 2 heads of superficial lumbrical muscle of cat activated by stimulation of a single motor axon. Sections will be used for autoradiography and for histochemistry. The numbers and cross sectional areas of the activated fibers will be related to conduction velocity of the motor axon to determine which factors cause the precise relation between motor unit force and conduction velocity in fatigue resistant units.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS017763-10
Application #
3861281
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Tychsen, Lawrence; Wong, Agnes Ming-Fong; Burkhalter, Andreas (2004) Paucity of horizontal connections for binocular vision in V1 of naturally strabismic macaques: Cytochrome oxidase compartment specificity. J Comp Neurol 474:261-75
Boero, J; Qin, W; Cheng, J et al. (2003) Restricted neuronal expression of ubiquitous mitochondrial creatine kinase: changing patterns in development and with increased activity. Mol Cell Biochem 244:69-76
Dagnew, Elias; Latchamsetty, Kalyan; Erinjeri, Joseph P et al. (2003) Glutamate receptor blockade alters the development of intracortical connections in rat barrel cortex. Somatosens Mot Res 20:77-84
Arikan, Rasim; Blake, Nicquet M J; Erinjeri, Joseph P et al. (2002) A method to measure the effective spread of focally injected muscimol into the central nervous system with electrophysiology and light microscopy. J Neurosci Methods 118:51-7
Mosconi, T; Snider, W D; Jacquin, M F (2001) Neurotrophin receptor expression in retrogradely labeled trigeminal nociceptors--comparisons with spinal nociceptors. Somatosens Mot Res 18:312-21
Epley, K D; Shainberg, M J; Lueder, G T et al. (2001) Pediatric secondary lens implantation in the absence of capsular support. J AAPOS 5:301-6
Carmichael, S T; Wei, L; Rovainen, C M et al. (2001) New patterns of intracortical projections after focal cortical stroke. Neurobiol Dis 8:910-22
Miller, B; Blake, N M; Erinjeri, J P et al. (2001) Postnatal growth of intrinsic connections in mouse barrel cortex. J Comp Neurol 436:17-31
Scott, C; Gusdorf, G; Tychsen, L (2000) Automated cover testing for binocular misalignment in awake monkeys using spectacle- mounted liquid crystal shutters. Binocul Vis Strabismus Q 15:59-66
Stark, K L; Kaufman, B; Lee, B C et al. (1999) Visual recovery after a year of craniopharyngioma-related amaurosis: report of a nine-year-old child and a review of pathophysiologic mechanisms. J AAPOS 3:366-71

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