Abstract

The Scientific-Clinical core has a Motor Neuron Disease (MND) Clinic as its central resource. The clinic evaluates MND patients and collects and distributes clinical specimens to members of the Program Project Grant. The clinic has a special interest in familial cases, atypical MND patients, post-poliomyelitis patients, and patients with viral or dysimmune abnormalities. The clinic is also involved in the following areas: (a) studies of familial MND, (b) an analysis of dysimmune abnormalities in MND, (c) neurophysiological, morphological and immunological studies of post-poliomyelitis syndrome, (d) acquisition of autopsy tissues from MND patients, (e) studies of the attitudes of patients, families and physicians towards life-sustaining support in MND, (f) implementation of experimental treatment protocols, (g) education of MND patients and families, and training of residents, fellows, and paramedical individuals in the diagnosis and care of MND patients. The Scientific core also stands as a repository of sera, spinal fluids and autopsy tissues from well-evaluated patients for investigators at large.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
3P01NS021442-16S1
Application #
6355610
Study Section
Project Start
2000-06-01
Project End
2001-05-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
16
Fiscal Year
2000
Total Cost
$293,069
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Thomas, Ajit G; Bodner, Amos; Ghadge, Ghanashyam et al. (2009) GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity. J Neurovirol 15:449-57
Haley, Benjamin; Paunesku, Tatjana; Proti?, Miroslava et al. (2009) Response of heterogeneous ribonuclear proteins (hnRNP) to ionising radiation and their involvement in DNA damage repair. Int J Radiat Biol 85:643-55
Nix, W A; Berger, M M; Oberste, M S et al. (2004) Failure to detect enterovirus in the spinal cord of ALS patients using a sensitive RT-PCR method. Neurology 62:1372-7
Rezania, Kourosh; Yan, Jianhua; Dellefave, Lisa et al. (2003) A rare Cu/Zn superoxide dismutase mutation causing familial amyotrophic lateral sclerosis with variable age of onset, incomplete penetrance and a sensory neuropathy. Amyotroph Lateral Scler Other Motor Neuron Disord 4:162-6
Ghadge, Ghanashyam D; Slusher, Barbara S; Bodner, Amos et al. (2003) Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Proc Natl Acad Sci U S A 100:9554-9
Woloschak, Gayle E; Paunesku, Tatjana; Protic, Miroslava (2002) Sensitivity to low-level radiation in radiosensitive ""wasted"" mice. Mil Med 167:42-3
Lee, J P; Gerin, C; Bindokas, V P et al. (2002) No correlation between aggregates of Cu/Zn superoxide dismutase and cell death in familial amyotrophic lateral sclerosis. J Neurochem 82:1229-38
Yang, Y; Hentati, A; Deng, H X et al. (2001) The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Nat Genet 29:160-5
Hirano, M; Hung, W Y; Cole, N et al. (2000) Multiple transcripts of the human Cu,Zn superoxide dismutase gene. Biochem Biophys Res Commun 276:52-6
Hosler, B A; Siddique, T; Sapp, P C et al. (2000) Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22. JAMA 284:1664-9

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