Abstract

We propose to conduct a pilot, double-blind, placebo-controlled, randomized clinical trial to treat acute ischemic stroke with a promising new anti-thrombotic agent, the platelet glycoprotein (GP) IIb/IIIa receptor inhibitor abciximab, and to employ a combination of clinical and novel MRI outcome measures, with the ultimate goal of integrating MRI technology into Phase II/III clinical trials of treatment of acute ischemia stroke. We expect that the data derived from this study will help determine whether treatment with abciximab in the acute phase of ischemic stroke results in improved early and chronic neurological outcome. This trial will also seek to define MRI surrogate markers of activity of t his therapeutic agent and to correlate clinical outcome assessment parameters with pre- and post-treatment MRI measures. MRI markers will be sought to discriminate those patients who are likely to respond to therapeutic agent from those who are unlikely to respond to the therapeutic agent because of advanced brain tissue injury. We believe that the results from the present study will lead to substantial improvements in the design and efficient of subsequent Phase II or III therapeutic clinical trials of acute ischemic stroke.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
2P01NS023393-14A1
Application #
6496373
Study Section
Project Start
1986-04-01
Project End
2005-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
14
Fiscal Year
2001
Total Cost
$173,158
Indirect Cost

  Institution

Name
Henry Ford Health System
Department
Type
DUNS #
073134603
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Knight, R A; Nagaraja, T N; Li, L et al. (2016) A Prospective Safety Trial of Atorvastatin Treatment to Assess Rebleeding after Spontaneous Intracerebral Hemorrhage: A Serial MRI Investigation. Austin J Cerebrovasc Dis Stroke 3:
Ding, Guang-Liang; Chopp, Michael; Li, Lian et al. (2014) Magnetic Resonance Imaging of Stroke in the Rat. Bo Pu Xue Za Zhi 31:116-132
Pindolia, Kirit; Li, Hong; Cardwell, Cisley et al. (2014) Characterization and functional analysis of cellular immunity in mice with biotinidase deficiency. Mol Genet Metab 112:49-56
Cui, Xu; Chopp, Michael; Zacharek, Alex et al. (2013) The neurorestorative benefit of GW3965 treatment of stroke in mice. Stroke 44:153-61
Zhang, Rui Lan; Zhang, Zheng Gang; Chopp, Michael (2013) Targeting nitric oxide in the subacute restorative treatment of ischemic stroke. Expert Opin Investig Drugs 22:843-51
Yan, Tao; Chopp, Michael; Ning, Ruizhuo et al. (2013) Intracranial aneurysm formation in type-one diabetes rats. PLoS One 8:e67949
Hernández-Vázquez, A; Wolf, B; Pindolia, K et al. (2013) Biotinidase knockout mice show cellular energy deficit and altered carbon metabolism gene expression similar to that of nutritional biotin deprivation: clues for the pathogenesis in the human inherited disorder. Mol Genet Metab 110:248-54
Xiong, Ye; Mahmood, Asim; Chopp, Michael (2013) Animal models of traumatic brain injury. Nat Rev Neurosci 14:128-42
Wang, Shiyang; Chopp, Michael; Nazem-Zadeh, Mohammad-Reza et al. (2013) Comparison of neurite density measured by MRI and histology after TBI. PLoS One 8:e63511
Wang, Lei; Chopp, Michael; Szalad, Alexandra et al. (2012) Thymosin ?4 promotes the recovery of peripheral neuropathy in type II diabetic mice. Neurobiol Dis 48:546-55

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