Abstract

This program project is a composite of four separate studies designed to explore in a highly integrated, multidisciplinary fashion, certain fundamental issues regarding the clinical and basic science of human immunodeficiency virus (HIV)- related neurological disease. The key study is a longitudinal study of asymptomatic, HIV seropositive individuals and sex, age and AIDS risk group matched controls for the development of neurological disease utilizing multiple parameters of assessment. Among the issues that will be addressed are the frequency with which neurological disease develops in association with HIV infection, the natural history of these disorders, and the identification of predictors for their development. Detailed clinical and laboratory evaluation of the study subjects with cerebrospinal fluid (CSF) analysis will allow us to explore the relationship of HIV-related neurological disease to the presence of HIV and the nature of the immune response to HIV, the presence of cytomegalovirus (CMV) and the nature the immune response to CMV, and the presence of brain reactive antibody.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS025569-02
Application #
3100184
Study Section
Neurological Disorders Program Project Review B Committee (NSPB)
Project Start
1988-02-01
Project End
1993-01-31
Budget Start
1989-02-01
Budget End
1990-01-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33101

  Publications

Schutzer, Steven E; Brunner, Michael; Fillit, Howard M et al. (2003) Autoimmune markers in HIV-associated dementia. J Neuroimmunol 138:156-61
Katz, D A; Berger, J R; Hamilton, B et al. (1994) Progressive multifocal leukoencephalopathy complicating Wiskott-Aldrich syndrome. Report of a case and review of the literature of progressive multifocal leukoencephalopathy with other inherited immunodeficiency states. Arch Neurol 51:422-6
Chodosh, J; Dix, R D; Howell, R C et al. (1994) Staining characteristics and antiviral activity of sulforhodamine B and lissamine green B. Invest Ophthalmol Vis Sci 35:1046-58
Berger, J R; David, N J (1993) Creutzfeldt-Jakob disease in a physician: a review of the disorder in health care workers. Neurology 43:205-6
Berger, J R; Flaster, M; Schatz, N et al. (1993) Cranial neuropathy heralding otherwise occult AIDS-related large cell lymphoma. J Clin Neuroophthalmol 13:113-8
Mizota, A; Dix, R D; Hamasaki, D I (1993) Bilateral electroretinographic changes induced by unilateral intra-visual cortex inoculation of herpes simplex virus type 1 in BALB/c mice. Doc Ophthalmol 84:213-30
Berger, J R; Pall, L; Winfield, D (1993) Effect of anabolic steroids on HIV-related wasting myopathy. South Med J 86:865-6
Berger, J R; Levy, R M (1993) The neurologic complications of human immunodeficiency virus infection. Med Clin North Am 77:1-23
Post, M J; Berger, J R; Duncan, R et al. (1993) Asymptomatic and neurologically symptomatic HIV-seropositive subjects: results of long-term MR imaging and clinical follow-up. Radiology 188:727-33
Berger, J R (1992) Spinal cord syphilis associated with human immunodeficiency virus infection: a treatable myelopathy. Am J Med 92:101-3

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