Abstract

Parkinson's Disease (PD) is a slowly developing syndrome. The syndrome evoked by MPTP, in contrast, has been observed almost exclusively as a sudden eruption evoked by relatively high acute doses. An animal model of PD capable of evaluating the therapeutic efficacy of neural transplants should embody the progressive features of idiopathic PD. It should also make provision for precise measures of function that can be relied on to trace the development of the syndrome and its response to this therapeutic strategy. To achieve such a model, monkeys will be treated chronically with low doses of MPTP calculated to induce a progressive impairment of motor function. Throughout the course of an experiment, function will be evaluated by a variety of measures. These measures include behavioral analyses, neurochemical analyses and morphological analyses. The data from this study should be of significant benefit in assessing the potential clinical role of nonfetal donor tissues in treating Parkinson's disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS025778-02
Application #
3902233
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Rochester
Department
Type
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Andersen, Anders H; Zhang, Zhiming; Avison, Malcolm J et al. (2002) Automated segmentation of multispectral brain MR images. J Neurosci Methods 122:13-23
Andersen, A H; Gash, D M; Avison, M J (1999) Principal component analysis of the dynamic response measured by fMRI: a generalized linear systems framework. Magn Reson Imaging 17:795-815
Chen, Q; Andersen, A H; Zhang, Z et al. (1999) Functional MRI of basal ganglia responsiveness to levodopa in parkinsonian rhesus monkeys. Exp Neurol 158:63-75
Gerhardt, G A; Cass, W A; Huettl, P et al. (1999) GDNF improves dopamine function in the substantia nigra but not the putamen of unilateral MPTP-lesioned rhesus monkeys. Brain Res 817:163-71
Gerhardt, G A; Cass, W A; Hudson, J et al. (1996) In vivo electrochemical studies of dopamine overflow and clearance in the striatum of normal and MPTP-treated rhesus monkeys. J Neurochem 66:579-88
Chen, Q; Andersen, A H; Zhang, Z et al. (1996) Mapping drug-induced changes in cerebral R2* by Multiple Gradient Recalled Echo functional MRI. Magn Reson Imaging 14:469-76
Gerhardt, G A; Cass, W A; Henson, M et al. (1995) Age-related changes in potassium-evoked overflow of dopamine in the striatum of the rhesus monkey. Neurobiol Aging 16:939-46
Hansen, J T; Sakai, K; Greenamyre, J T et al. (1995) Sprouting of dopaminergic fibers from spared mesencephalic dopamine neurons in the unilateral partial lesioned rat. Brain Res 670:197-204
Cass, W A; Gerhardt, G A; Zhang, Z et al. (1995) Increased dopamine clearance in the non-lesioned striatum of rhesus monkeys with unilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) striatal lesions. Neurosci Lett 185:52-5
Gash, D M; Zhang, Z; Cass, W A et al. (1995) Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys. J Comp Neurol 363:345-58

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