Abstract

This program project application aims to continue studies on the molecular and biophysical mechanisms involved in neuronal signalling by the neurobiology group of the Biology Department at UCSD. Six separate projects, using a wide variety of animal models, from leeches and fruit flies to lobsters and frogs, will be undertaken. Ion channels, their regulation and modulation represent a major focus of the work since they represent identified membrane components of fundamental importance to neuronal signalling. Second messengers and intracellular cascade systems also represent a central unifying theme. Target selection during development and target mediated neuronal differentiation represent other foci of integrative signalling. The diversity of approaches provide an integrated analysis of signalling mechanisms from the molecular level to the functioning circuit.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS025916-07
Application #
2265725
Study Section
Special Emphasis Panel (SRC (01))
Project Start
1988-03-01
Project End
1996-02-29
Budget Start
1994-03-01
Budget End
1995-02-28
Support Year
7
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Gurantz, D; Lautermilch, N J; Watt, S D et al. (2000) Sustained upregulation in embryonic spinal neurons of a Kv3.1 potassium channel gene encoding a delayed rectifier current. J Neurobiol 42:347-56
Reynolds, S A; French, K A; Baader, A et al. (1998) Staging of middle and late embryonic development in the medicinal leech, Hirudo medicinalis. J Comp Neurol 402:155-67
Szczupak, L; Edgar, J; Peralta, M L et al. (1998) Long-lasting depolarization of leech neurons mediated by receptors with a nicotinic binding site. J Exp Biol 201:1895-906
Cleland, T A; Selverston, A I (1998) Inhibitory glutamate receptor channels in cultured lobster stomatogastric neurons. J Neurophysiol 79:3189-96
French, K A; Murphy, J A; Szczupak, L (1998) Target tissues affect cellular properties of cocultured leech Retzius neurons. J Neurobiol 34:55-68
Kristan Jr, W B; Shaw, B K (1997) Population coding and behavioral choice. Curr Opin Neurobiol 7:826-31
Rothhut, B; Romano, S J; Vijayaraghavan, S et al. (1996) Post-translational regulation of neuronal acetylcholine receptors stably expressed in a mouse fibroblast cell line. J Neurobiol 29:115-25
Gurantz, D; Ribera, A B; Spitzer, N C (1996) Temporal regulation of Shaker- and Shab-like potassium channel gene expression in single embryonic spinal neurons during K+ current development. J Neurosci 16:3287-95
Rathouz, M M; Vijayaraghavan, S; Berg, D K (1995) Acetylcholine differentially affects intracellular calcium via nicotinic and muscarinic receptors on the same population of neurons. J Biol Chem 270:14366-75
Vijayaraghavan, S; Huang, B; Blumenthal, E M et al. (1995) Arachidonic acid as a possible negative feedback inhibitor of nicotinic acetylcholine receptors on neurons. J Neurosci 15:3679-87

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