Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL013423-26
Application #
2214742
Study Section
Special Emphasis Panel (NSS)
Project Start
1975-02-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
26
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Notre Dame
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
824910376
City
Notre Dame
State
IN
Country
United States
Zip Code
46556

  Publications

Miles, L A; Baik, N; Bai, H et al. (2018) The plasminogen receptor, Plg-RKT, is essential for mammary lobuloalveolar development and lactation. J Thromb Haemost 16:919-932
Urano, T; Castellino, F J; Suzuki, Y (2018) Regulation of plasminogen activation on cell surfaces and fibrin. J Thromb Haemost :
Glinton, Kristofor; Beck, Julia; Liang, Zhong et al. (2017) Variable region in streptococcal M-proteins provides stable binding with host fibrinogen for plasminogen-mediated bacterial invasion. J Biol Chem 292:6775-6785
Yuan, Yue; Zajicek, Jaroslav; Qiu, Cunjia et al. (2017) Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen. J Biol Chem 292:15016-15027
Bao, Yun-Juan; Liang, Zhong; Mayfield, Jeffrey A et al. (2016) Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity. J Bacteriol 198:1712-24
Motley, Michael P; Madsen, Daniel H; Jürgensen, Henrik J et al. (2016) A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo. Blood 127:1085-96
Chandrahas, Vishwanatha; Glinton, Kristofor; Liang, Zhong et al. (2015) Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein. J Biol Chem 290:18833-42
Bao, Yun-Juan; Liang, Zhong; Mayfield, Jeffrey A et al. (2015) CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants. J Bacteriol 197:3191-205
Gupta, Kamlesh K; Donahue, Deborah L; Sandoval-Cooper, Mayra J et al. (2015) Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia. PLoS One 10:e0120728
Bao, Yunjuan; Liang, Zhong; Booyjzsen, Claire et al. (2014) Unique genomic arrangements in an invasive serotype M23 strain of Streptococcus pyogenes identify genes that induce hypervirulence. J Bacteriol 196:4089-102

Showing the most recent 10 out of 125 publications