Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37HL013423-20A1
Application #
3485355
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1975-02-01
Project End
1995-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
20
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Notre Dame
Department
Type
Schools of Arts and Sciences
DUNS #
824910376
City
Notre Dame
State
IN
Country
United States
Zip Code
46556

  Publications

Miles, L A; Baik, N; Bai, H et al. (2018) The plasminogen receptor, Plg-RKT, is essential for mammary lobuloalveolar development and lactation. J Thromb Haemost 16:919-932
Urano, T; Castellino, F J; Suzuki, Y (2018) Regulation of plasminogen activation on cell surfaces and fibrin. J Thromb Haemost :
Glinton, Kristofor; Beck, Julia; Liang, Zhong et al. (2017) Variable region in streptococcal M-proteins provides stable binding with host fibrinogen for plasminogen-mediated bacterial invasion. J Biol Chem 292:6775-6785
Yuan, Yue; Zajicek, Jaroslav; Qiu, Cunjia et al. (2017) Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen. J Biol Chem 292:15016-15027
Bao, Yun-Juan; Liang, Zhong; Mayfield, Jeffrey A et al. (2016) Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity. J Bacteriol 198:1712-24
Motley, Michael P; Madsen, Daniel H; Jürgensen, Henrik J et al. (2016) A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo. Blood 127:1085-96
Chandrahas, Vishwanatha; Glinton, Kristofor; Liang, Zhong et al. (2015) Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein. J Biol Chem 290:18833-42
Bao, Yun-Juan; Liang, Zhong; Mayfield, Jeffrey A et al. (2015) CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants. J Bacteriol 197:3191-205
Gupta, Kamlesh K; Donahue, Deborah L; Sandoval-Cooper, Mayra J et al. (2015) Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia. PLoS One 10:e0120728
Mayfield, Jeffrey A; Liang, Zhong; Agrahari, Garima et al. (2014) Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence. PLoS One 9:e100698

Showing the most recent 10 out of 125 publications