Abstract

This research program is designed to characterize specific processes that are used in the later (""""""""higher"""""""") stages of visual object recognition. Adult patients with focal brain damage will be tested on four types of visual tasks: 1. The selection and focus of visual attention over space. 2 . The recognition and encoding of object properties (particularly shape). 3 . The encoding of spatial properties (location, orientation, and size), and 4. The use of stored visual information to guide top-down search. A deficit will be assessed by comparing the relative differences in response times and error rates in each task for patients with the corresponding differences for age-, sex-, and education-matched normal control subjects. The hypotheses to be tested are based on a computational analysis and a computer simulation model previously developed by the researchers. Behavioral deficits will be correlated with the location of lesions as defined by MRI neuro-imaging studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS027950-04
Application #
5215310
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Makris, N; Kennedy, D N; Boriel, D L et al. (2010) Methods of MRI-based structural imaging in the aging monkey. Methods 50:166-77
Kennedy, David N; Haselgrove, Christian; Makris, Nikos et al. (2010) WebParc: a tool for analysis of the topography and volume of stroke from MRI. Med Biol Eng Comput 48:215-28
Makris, Nikos; Caviness, Verne S; Kennedy, David N (2005) An introduction to MR imaging-based stroke morphometry. Neuroimaging Clin N Am 15:325-39, x
Herbert, M R; Ziegler, D A; Deutsch, C K et al. (2005) Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis. Brain 128:213-26
Herbert, Martha R; Ziegler, David A; Makris, Nikos et al. (2004) Localization of white matter volume increase in autism and developmental language disorder. Ann Neurol 55:530-40
Herbert, M R; Ziegler, D A; Deutsch, C K et al. (2003) Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys. Brain 126:1182-92
Caviness, V S; Makris, N; Montinaro, E et al. (2002) Anatomy of stroke, Part II: volumetric characteristics with implications for the local architecture of the cerebral perfusion system. Stroke 33:2557-64
Caviness, V S; Makris, N; Montinaro, E et al. (2002) Anatomy of stroke, Part I: an MRI-based topographic and volumetric System of analysis. Stroke 33:2549-56
Caviness Jr, V S; Makris, N; Lange, N T et al. (2000) Advanced applications of MRI in human brain science. Keio J Med 49:66-73
Curran, T; Schacter, D L; Galluccio, L (1999) Cross-modal priming and explicit memory in patients with verbal production deficits. Brain Cogn 39:133-46

Showing the most recent 10 out of 29 publications