Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS031998-03
Application #
2269967
Study Section
Special Emphasis Panel (SRC (06))
Project Start
1993-09-01
Project End
1997-08-31
Budget Start
1995-09-01
Budget End
1997-08-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Surgery
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
Posmantur, R M; Zhao, X; Kampfl, A et al. (1998) Immunoblot analyses of the relative contributions of cysteine and aspartic proteases to neurofilament breakdown products following experimental brain injury in rats. Neurochem Res 23:1265-76
Newcomb, J K; Kampfl, A; Posmantur, R M et al. (1997) Immunohistochemical study of calpain-mediated breakdown products to alpha-spectrin following controlled cortical impact injury in the rat. J Neurotrauma 14:369-83
Dixon, C E; Ma, X; Marion, D W (1997) Reduced evoked release of acetylcholine in the rodent neocortex following traumatic brain injury. Brain Res 749:127-30
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Posmantur, R; Kampfl, A; Siman, R et al. (1997) A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat. Neuroscience 77:875-88
Dixon, C E; Flinn, P; Bao, J et al. (1997) Nerve growth factor attenuates cholinergic deficits following traumatic brain injury in rats. Exp Neurol 146:479-90
Le, W; Yang, K; Whitson, J S et al. (1996) Liposome-mediated NGF gene transfection increases ChAT activity in CNS cell cultures. Neuroreport 7:710-2
Kampfl, A; Posmantur, R; Nixon, R et al. (1996) mu-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury. J Neurochem 67:1575-83
Dixon, C E; Bao, J; Long, D A et al. (1996) Reduced evoked release of acetylcholine in the rodent hippocampus following traumatic brain injury. Pharmacol Biochem Behav 53:679-86

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