Abstract

The Transgenic Animal Model Core will be responsible for making all transgenic mice described in this Program Project application. The investigator will design and generate the gene construct. The Core will do the microinjections to produce the transgenic mice. The Core will provide the investigator with a sample of tail DNA or peripheral blood for analysis, and the investigator will report which mice contain the transgene. The Core will establish the lines of transgenic mice, and will freeze embryos from each line, if desired. Once a line is established, the Core will maintain the line to provide sufficient experimental mice for the investigator.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS038468-03
Application #
6652313
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
3
Fiscal Year
2002
Total Cost
$195,163
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Watzlawik, Jens O; Painter, Meghan M; Wootla, Bharath et al. (2015) A human anti-polysialic acid antibody as a potential treatment to improve function in multiple sclerosis patients. J Nat Sci 1:
Pavelko, Kevin D; Mendez-Fernandez, Yanice; Bell, Michael P et al. (2012) Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity. PLoS Pathog 8:e1002541
Mangalam, Ashutosh K; Luckey, David; Giri, Shailendra et al. (2012) Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice. J Autoimmun 38:344-53
Kerkvliet, Jason; Edukulla, Ramakrishna; Rodriguez, Moses (2010) Novel roles of the picornaviral 3D polymerase in viral pathogenesis. Adv Virol 2010:368068
Warrington, Arthur E; Rodriguez, Moses (2010) Method of identifying natural antibodies for remyelination. J Clin Immunol 30 Suppl 1:S50-5
Deb, Chandra; Lafrance-Corey, Reghann G; Zoecklein, Laurie et al. (2009) Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis. J Neuropathol Exp Neurol 68:1037-48
Rodriguez, Moses; Warrington, Arthur E; Pease, Larry R (2009) Invited Article: Human natural autoantibodies in the treatment of neurologic disease. Neurology 72:1269-76
Rodriguez, Moses; Zoecklein, Laurie; Papke, Louisa et al. (2009) Tumor necrosis factor alpha is reparative via TNFR2 [corrected] in the hippocampus and via TNFR1 [corrected] in the striatum after virus-induced encephalitis. Brain Pathol 19:12-26
Wright, Brent R; Warrington, Arthur E; Edberg, Dale D et al. (2009) Cellular mechanisms of central nervous system repair by natural autoreactive monoclonal antibodies. Arch Neurol 66:1456-9
Rodriguez, Moses; Zoecklein, Laurie; Kerkvliet, Jason G et al. (2008) Human HLA-DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination. J Virol 82:3369-80

Showing the most recent 10 out of 48 publications