Abstract

The Transgenic Mouse Core B Facility has four major aims: 1. To maintain breeding colonies of transgenic mouse lines and to provide cohorts of transgenic mice for studies proposed in Projects 1, 2 and 3 of this Program Project grant. 2. To establish C57BL6 congenic lines of the transgenic mice use throughout the study. 3. To generate new transgenic and knock-in mice carrying functional mutations to PARP. 4. To generate PARG knockout mice. The Transgenic Mouse Core B Facility will be a shared resource of the Program Project grant and will play a central role in our investigations in the pathogenesis of Stroke and Neuronal Injury.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
1P01NS039148-01
Application #
6232801
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
1999-08-06
Project End
2004-04-30
Budget Start
Budget End
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Fatokun, A A; Liu, J O; Dawson, V L et al. (2013) Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos. Br J Pharmacol 169:1263-78
Kang, Ho Chul; Lee, Yun-Il; Shin, Joo-Ho et al. (2011) Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. Proc Natl Acad Sci U S A 108:14103-8
Wang, Yingfei; Kim, No Soo; Haince, Jean-Francois et al. (2011) Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci Signal 4:ra20
Andrabi, Shaida A; Kang, Ho Chul; Haince, Jean-François et al. (2011) Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death. Nat Med 17:692-9
Li, Xiaoling; Klaus, Judith A; Zhang, Jian et al. (2010) Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia. J Neurochem 113:1012-22
Xu, Zhenfeng; Zhang, Jian; David, Karen K et al. (2010) Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia. Am J Physiol Regul Integr Comp Physiol 299:R215-21
Kishimoto, Koji; Li, Rung-Chi; Zhang, Jian et al. (2010) Cytosolic phospholipase A2 alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice. J Neuroinflammation 7:42
Wang, Yingfei; Kim, No S; Li, Xiaoling et al. (2009) Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos). J Neurochem 110:687-96
Yu, Seong-Woon; Wang, Yingfei; Frydenlund, Didrik S et al. (2009) Outer mitochondrial membrane localization of apoptosis-inducing factor: mechanistic implications for release. ASN Neuro 1:
Wang, Yingfei; Dawson, Valina L; Dawson, Ted M (2009) Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol 218:193-202

Showing the most recent 10 out of 27 publications