This application is in response to RFA-MH-04-003, """"""""Developing Centers on Intervention for the Prevention of Suicide (DCIPS)."""""""" While there is a high incidence of suicide and suicide attempts in the United States, research on effective treatments for this population has lagged far behind. Fewer than forty randomized controlled trials of suicide interventions, either pharmacological or psychosocial have been conducted. Thus, the most deadly condition in psychiatry has received the least attention from a clinical trials perspective and many commonly used interventions have never been tested empirically. The most significant risk factors for suicide are prior suicidal behavior, serious and persistent suicide ideation and co-morbid alcohol (AUD) and substance use disorders (SUD). In an effort to develop interventions that have a direct impact on reducing suicide attempts and suicide, this high-risk segment of the suicidal population is the focus of our Center. Interventions that are readily exportable and easily trained, such as medication strategies and brief psychosocial interventions will be targeted. The primary goals, each with a training component, are related to high suicide risk individuals, both adolescent and adult: 1. to promote, develop and conduct efficacy studies that test and adapt pharmacological, psychosocial and combined interventions targeting suicidal behaviors; 2. to stimulate ethically and clinically-sound inclusion of suicidal individuals in intervention studies, from which they are typically excluded targeting their primary disorder, e.g. depression, bipolar disorder, AUD and SUD; 3. to develop a model of partnership and network with local Psychiatric Emergency Rooms to develop a more effective referral and follow-up process for suicidal individuals; and 4. to develop strategies to enhance treatment engagement, adherence and retention of suicidal individuals both following ER visits and after recruitment into intervention trials; 5. to enhance reliable and accurate suicide assessment and measurement development for suicide intervention trials; and 6. to develop strategies for understanding and managing the complex clinical and ethical issues in conducting suicide intervention research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Exploratory Grants (P20)
Project #
5P20AA015630-04
Application #
7280779
Study Section
Special Emphasis Panel (ZMH1-CRB-C (11))
Program Officer
Chiapella, Page
Project Start
2004-09-24
Project End
2009-08-31
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
4
Fiscal Year
2007
Total Cost
$627,834
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Dervic, K; Garcia-Amador, M; Sudol, K et al. (2015) Bipolar I and II versus unipolar depression: clinical differences and impulsivity/aggression traits. Eur Psychiatry 30:106-13
Brown, Gregory K; Currier, Glenn W; Jager-Hyman, Shari et al. (2015) Detection and classification of suicidal behavior and nonsuicidal self-injury behavior in emergency departments. J Clin Psychiatry 76:1397-403
MacGregor, Erica K; Grunebaum, Michael F; Galfalvy, Hanga C et al. (2014) Depressed parents' attachment: effects on offspring suicidal behavior in a longitudinal family study. J Clin Psychiatry 75:879-85
Oquendo, M A; Perez-Rodriguez, M M; Poh, E et al. (2014) Life events: a complex role in the timing of suicidal behavior among depressed patients. Mol Psychiatry 19:902-9
Miano, Annemarie; Fertuck, Eric A; Arntz, Arnoud et al. (2013) Rejection sensitivity is a mediator between borderline personality disorder features and facial trust appraisal. J Pers Disord 27:442-56
Oquendo, Maria A; Ellis, Steven P; Chesin, Megan S et al. (2013) Familial transmission of parental mood disorders: unipolar and bipolar disorders in offspring. Bipolar Disord 15:764-73
Fournier, Jay C; Keener, Matthew T; Almeida, Jorge et al. (2013) Amygdala and whole-brain activity to emotional faces distinguishes major depressive disorder and bipolar disorder. Bipolar Disord 15:741-52
Wilson, Scott T; Stanley, Barbara; Brent, David A et al. (2012) Interaction between tryptophan hydroxylase I polymorphisms and childhood abuse is associated with increased risk for borderline personality disorder in adulthood. Psychiatr Genet 22:15-24
Sher, Leo; Stanley, Barbara H; Posner, Kelly et al. (2012) Decreased suicidal ideation in depressed patients with or without comorbid posttraumatic stress disorder treated with selective serotonin reuptake inhibitors: an open study. Psychiatry Res 196:261-6
Fertuck, Eric A; Keilp, John; Song, Inkyung et al. (2012) Higher executive control and visual memory performance predict treatment completion in borderline personality disorder. Psychother Psychosom 81:38-43

Showing the most recent 10 out of 36 publications