Abstract

The Tumor Bank Core Facility will collect and maintain frozen samples of brain tumor and discarded samples of normal brain tissue removed at surgery. Tissues will be histologically defined and cataloged. Samples will be made available for molecular biologic as well as for immunologic epitope and receptor characterizations. In addition, a small portion of each tumor will be cultured and carried as an explant. Ideally, every tumor will have both solid primary tumor and explants available for research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory Grants (P20)
Project #
5P20CA060171-02
Application #
3751852
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Chen, W S; Kung, H J; Yang, W K et al. (1999) Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa. Int J Cancer 83:579-84
Qiu, Y; Robinson, D; Pretlow, T G et al. (1998) Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. Proc Natl Acad Sci U S A 95:3644-9
McKeon, R J; Silver, J; Large, T H (1997) Expression of full-length trkB receptors by reactive astrocytes after chronic CNS injury. Exp Neurol 148:558-67
Zhang, D; Jacobberger, J W (1996) TGF-beta 1 perturbation of the fibroblast cell cycle during exponential growth: switching between negative and positive regulation. Cell Prolif 29:289-307
Garner, A S; Menegay, H J; Boeshore, K L et al. (1996) Expression of TrkB receptor isoforms in the developing avian visual system. J Neurosci 16:1740-52
Ling, L; Templeton, D; Kung, H J (1996) Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase. J Biol Chem 271:18355-62
Ling, L; Kung, H J (1995) Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase. Mol Cell Biol 15:6582-92
Garner, A S; Large, T H (1994) Isoforms of the avian TrkC receptor: a novel kinase insertion dissociates transformation and process outgrowth from survival. Neuron 13:457-72
Shu, H K; Chang, C M; Ravi, L et al. (1994) Modulation of erbB kinase activity and oncogenic potential by single point mutations in the glycine loop of the catalytic domain. Mol Cell Biol 14:6868-78