An In vivo Cellular and Molecular Imaging Center (ICMIC) at the University of Pennsylvania will provide imaging resources and expertise to molecular biologists and clinicians engaged in research on molecular markers of cancer in small animal models and human subjects, respectively. The imaging center, which will be called the Mid-Atlantic Molecular Imaging Center (MAMIC), will serve the greater Philadelphia area as well as a number of outstanding institutions throughout the world. Three imaging modalities will be employed, Nuclear Medicine (including PET and SPECT), NMR (including MRI and MRS), and Optical Imaging (focusing primarily on near infrared imaging, but also including redox scanning of ex vivo specimens). The proposed MAMIC will support a number of interdisciplinary highly interactive projects in three major research areas: 1) Tumor Biology, 2) Gene and Antiangiogenic Therapy, and 3) Radiation Oncology. Core facilities for Molecular Biology, Chemistry, Biostatistics, and the three Imaging modalities are included. The proposal includes six potential developmental projects entitled: 1) Mechanism of apoptosis induction, 2) Peptidomimetic ligands of HER2/Neu receptors in breast cancer, 3) Targeting of LDL receptors on tumor cells, 4) Mechanism of estrogen/tamoxifen effects on Gd enhancement of breast tumor MR images, 5) Treatment of colon tumor liver metastases by interferon transfection using creatine kinase as a marker gene, and 6) Bacteriochlorophyll molecular beacons triggered by specific mRNAs. In addition to support for three developmental projects, the MAMIC will provide core facilities, seminars and assistance in obtaining external funding to all the participants. Each of the Imaging Core Facilities will conduct research directed at development of imaging techniques that will enhance the research programs of the participating scientific community. This imaging research will be supported by a Small Animal Imaging Grant that is in the process of being funded and a Research Resource grant that has supported research in magnetic resonance and optical imaging for the past 15 years. The MAMIC will therefore serve as a catalyst and focal point for ongoing cancer research employing state of the art imaging techniques.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory Grants (P20)
Project #
5P20CA086255-02
Application #
6377882
Study Section
Special Emphasis Panel (ZCA1-SRRB-3 (J2))
Project Start
2000-09-12
Project End
2003-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
2
Fiscal Year
2001
Total Cost
$400,000
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Glickson, Jerry D; Lund-Katz, Sissel; Zhou, Rong et al. (2009) Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agents. Adv Exp Med Biol 645:227-39
Glickson, Jerry D; Lund-Katz, Sissel; Zhou, Rong et al. (2008) Lipoprotein nanoplatform for targeted delivery of diagnostic and therapeutic agents. Mol Imaging 7:101-10
Li, Zijun; Qiao, Hui; Lebherz, Corinna et al. (2005) Creatine kinase, a magnetic resonance-detectable marker gene for quantification of liver-directed gene transfer. Hum Gene Ther 16:1429-38
Milkevitch, Matthew; Shim, Hyunsuk; Pilatus, Ulrich et al. (2005) Increases in NMR-visible lipid and glycerophosphocholine during phenylbutyrate-induced apoptosis in human prostate cancer cells. Biochim Biophys Acta 1734:1-12
Wu, Sophia P; Lee, Intae; Ghoroghchian, P Peter et al. (2005) Near-infrared optical imaging of B16 melanoma cells via low-density lipoprotein-mediated uptake and delivery of high emission dipole strength tris[(porphinato)zinc(II)] fluorophores. Bioconjug Chem 16:542-50
Li, Hui; Zhang, Zhihong; Blessington, Dana et al. (2004) Carbocyanine labeled LDL for optical imaging of tumors. Acad Radiol 11:669-77
Li, Hui; Gray, Brian D; Corbin, Ian et al. (2004) MR and fluorescent imaging of low-density lipoprotein receptors. Acad Radiol 11:1251-9
Zhang, Zhihong; Li, Hui; Liu, Qian et al. (2004) Metabolic imaging of tumors using intrinsic and extrinsic fluorescent markers. Biosens Bioelectron 20:643-50
Zhang, Zhihong; Blessington, Dana; Li, Hui et al. (2004) Redox ratio of mitochondria as an indicator for the response of photodynamic therapy. J Biomed Opt 9:772-8
Tailor, Dharmesh R; Poptani, Harish; Glickson, Jerry D et al. (2003) High-resolution assessment of blood flow in murine RIF-1 tumors by monitoring uptake of H(2)(17)O with proton T(1rho)-weighted imaging. Magn Reson Med 49:1-6

Showing the most recent 10 out of 14 publications