Abstract

The goal of the pilot research program is to promote innovative research in cancer and aging related to the three theme areas we have chosen; immunobiology of aging and cancer, treatment tolerance and efficacy in the context of aging comorbidity and behavioral/social issues. Pilots will be selected based on responsiveness to the goals of the program; evidence of involvement of and plans for collaboration between scholars in cancer and aging, specific plans and potential to lead to independent external funding, feasibility in the financial and time frame proposed and traditional measures of quality including significance, approach, innovation, investigator and environment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory Grants (P20)
Project #
1P20CA103730-01
Application #
6825266
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2003-09-30
Project End
2008-08-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2003
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Zhao, Jing; Li, Xuesen; McGowan, Sara et al. (2015) NF-?B activation with aging: characterization and therapeutic inhibition. Methods Mol Biol 1280:543-57
Tilstra, Jeremy S; Gaddy, Daniel F; Zhao, Jing et al. (2014) Pharmacologic IKK/NF-?B inhibition causes antigen presenting cells to undergo TNF? dependent ROS-mediated programmed cell death. Sci Rep 4:3631
Hudson, Alana G; Reeves, Katherine W; Modugno, Francesmary et al. (2013) Erythrocyte omega-6 and omega-3 fatty acids and mammographic breast density. Nutr Cancer 65:410-6
Xun, Zhiyin; Rivera-Sánchez, Sulay; Ayala-Peña, Sylvette et al. (2012) Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Rep 2:1137-42
Tilstra, Jeremy S; Robinson, Andria R; Wang, Jin et al. (2012) NF-?B inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest 122:2601-12
Kovacs, J R; Li, C; Yang, Q et al. (2012) Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery. Cell Death Differ 19:144-52
Powolny, Anna A; Singh, Shivendra V; Melov, Simon et al. (2011) The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation. Exp Gerontol 46:441-52
Wieckowski, Eva; Chatta, Gurkamal S; Mailliard, Robbie M et al. (2011) Type-1 polarized dendritic cells loaded with apoptotic prostate cancer cells are potent inducers of CD8(+) T cells against prostate cancer cells and defined prostate cancer-specific epitopes. Prostate 71:125-33
Tilstra, Jeremy S; Clauson, Cheryl L; Niedernhofer, Laura J et al. (2011) NF-?B in Aging and Disease. Aging Dis 2:449-65
Ghosh, Hiyaa Singhee; Reizis, Boris; Robbins, Paul D (2011) SIRT1 associates with eIF2-alpha and regulates the cellular stress response. Sci Rep 1:150

Showing the most recent 10 out of 47 publications