Priority-Setting StagePilot Project #1 (Drs. Davidson and Hsieh) is fully conceived, planned and staffed. Consequently thisproject will be implemented immediately upon funding. Pilot project #2 will be selected during Year 1 by aPriority-setting process described as follows.We have selected an Internal Advisory Committee comprised of 6 cancer investigators: The two Lead Pisplus 2 additional members from each institution:Alec J. Davidson, PhD is an assistant professor in the Department of Anatomy and Neurobiology, and amember of the Neuroscience Institute and Circadian Rhythms and Sleep Disorders Program. Dr. Davidsonhas been pursuing research on the relationship between circadian clocks and cancer for 4 years, and iscurrently PI of an R21 grant from NCI to investigate this issue in a rat model of hepatocellular carcinoma. He isthe MSM Lead-Pi of this grant application.Sandra Harris-Hooker, PhD is the Vice President and Associate Dean for Sponsored ResearchAdministration at MSM, and the Director of the Minority Biomedical Research Support Program at MorehouseSchool of Medicine, a program dedicated to the development of future biomedical research scholars. Withprofessional training in Cell Biology, and postgraduate emphasis in Cardiovascular Pathology, Dr. Harris-Hooker has worked in the area of vascular cell biology for over 20 years, studying enddthelial dysfunctionsinvolved in the pathogenesis of atherosclerosis. While her primary research area is vascular biology, she isalso interested in ways by which to enhance the integration of basic, clinical and population-based research inorder to address disparities in health. Dr. Harris-Hooker has been on the MSM faculty since 1983.Daniel Blumenthal, MD, MPH, is Chairman of the Department of Community Health and Preventive Medicineand Principal Investigator of the Morehouse School of Medicine Prevention Research Center (PRC). Themission of the PRC is to advance scientific knowledge in the field of prevention of disease in African Americanand other minority communities and to disseminate new information and strategies of prevention. Specifically,Dr. Blumenthal is PI of the Cancer Prevention and Control Research network within the PRC, whose mission itis to accelerate the adoption of evidence-based cancer prevention and control in minority communities.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory Grants (P20)
Project #
5P20CA132388-02
Application #
7678485
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
2
Fiscal Year
2008
Total Cost
$100,823
Indirect Cost
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Li, Guang; Wei, Jie; Kadbi, Mo et al. (2017) Novel Super-Resolution Approach to Time-Resolved Volumetric 4-Dimensional Magnetic Resonance Imaging With High Spatiotemporal Resolution for Multi-Breathing Cycle Motion Assessment. Int J Radiat Oncol Biol Phys 98:454-462
Wang, Ruoxiang; Sun, Xiaojuan; Wang, Christopher Y et al. (2012) Spontaneous cancer-stromal cell fusion as a mechanism of prostate cancer androgen-independent progression. PLoS One 7:e42653
Zhau, Haiyen E; He, Hui; Wang, Christopher Y et al. (2011) Human prostate cancer harbors the stem cell properties of bone marrow mesenchymal stem cells. Clin Cancer Res 17:2159-69
He, Hui; Davidson, Alec J; Wu, Daqing et al. (2010) Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells. Prostate 70:1119-26
Sun, Xiaojuan; He, Hui; Xie, Zhihui et al. (2010) Matched pairs of human prostate stromal cells display differential tropic effects on LNCaP prostate cancer cells. In Vitro Cell Dev Biol Anim 46:538-46
Thalmann, George N; Rhee, Hong; Sikes, Robert A et al. (2010) Human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in LNCaP Cells. Eur Urol 58:162-71
He, Hui; Xu, Jianchun; Nelson, Peter S et al. (2010) Differential expression of the alpha2 chain of the interleukin-13 receptor in metastatic human prostate cancer ARCaPM cells. Prostate 70:993-1001
He, Hui; Yang, Xiaojian; Davidson, Alec J et al. (2010) Progressive epithelial to mesenchymal transitions in ARCaP E prostate cancer cells during xenograft tumor formation and metastasis. Prostate 70:518-28
Wang, Ruoxiang; He, Hui; Sun, Xiaojuan et al. (2009) Transcription variants of the prostate-specific PrLZ gene and their interaction with 14-3-3 proteins. Biochem Biophys Res Commun 389:455-60
Odero-Marah, Valerie A; Wang, Ruoxiang; Chu, Gina et al. (2008) Receptor activator of NF-kappaB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells. Cell Res 18:858-70