Abstract

OFTHEPLANNINGUNITCOMPONENT AscancerandCVDarerapidlyincreasingitsdiseaseburdeninSouthAmerica,thereisan urgentneedtoimprovetheirpreventionandcontrolstrategies,informedbyhighquality research.Unfortunately,thedearthofadequatepopulation?baseddataaswellasthelimited researchinfrastructureandfunding,challengeNCDresearch,andparticularlycancerresearch effortsintheregion.Since2010,CESCASandCRONICAShaveassembledtwopopulation?based prospectivecohortsformerlyfundedbyNIH/NHLBIuntil2014?2015.Thesecohortsrecruitedat baseline~11000adultsrandomlysampledfromthegeneralpopulationfromfourcitiesin Argentina,ChileandUruguay,andthreecitiesinPeru,respectively.Thestudiesweredesigned toestimatetheprevalenceaswellasthelongtermincidenceofcardio?metabolicdiseasesand theirriskfactorsinadultswithoutCVDatbaselineLeveragedawell?developedresearch infrastructure,thecentersofArgentinaandPeruaimtoexpandtheirresearchcapacityin cardiovascularepidemiologytowardscancerepidemiology,byjoiningthedivisionof PopulationScienceofDFCI.Wewilldevelopapopulation?basedcancerandCVDresearch programbasedonourpreviousworkperformedbythecentersofArgentinaandPeruthrough theirrespectiveprospectivecohortstudiesinArgentina,Chile,UruguayandPeru,respectively. Byintegratingthesetwoprogramswewillbeabletoidentifycommonriskfactorsandcausal pathwaysthatmayinfluencethedevelopmentofbothCVDandcancerinSouthAmerica.In addition,wewillperformajoinpilotprojectfocusedonthegeo?mappingofprevalence, incidenceandmortalityusingGIStechnology,forGallbladderandGastricCancer.Bothcancers havehigherincidenceinSouthAmerica,comparedtotherestoftheworld.SACRENwillalso developresearchenhancementactivitiesfocusedonlearningspecificknowledgeandskills, includinghands?onpracticeandmentoring,aimedatstrengtheningtheabilitiesofearly?stage researchersandresearchsupportstaff.Finally,weaimtoidentifythesharedcorefacilities eachpartnerwillcontributetoSACRENtosupportitsresearchprojects,suchasdata managementandanalysis,biobankshandling,andcommunicationplatforms,exploring mechanismstoshareinfrastructureandresourcestoavoidduplicationandredundancies,and definingexplicitlytherulesandregulationsforitscommonuse.

Public Health Relevance

OFTHEPLANNINGUNITCOMPONENT AscancerandCVDarerapidlyincreasingitsdiseaseburdeninSouthAmerica,thereisanurgent needtoimprovetheirpreventionandcontrolstrategies,informedbyhighqualityresearch.We willdevelopapopulation?basedcancerandCVDresearchprogrambasedonourpreviouswork performedbythecentersofArgentinaandPeruthroughtheirrespectiveprospectivecohort studiesinArgentina,Chile,UruguayandPeru,respectively.Inaddition,wewillperformajoinpilot projectfocusedonthegeo?mappingofprevalence,incidenceandmortalityusingGIStechnology, forGallbladderandGastricCancer.BothcancershavehigherincidenceinSouthAmerica, comparedtotherestoftheworld.SACRENwillalsodevelopresearchenhancementactivities focusedonlearningspecificknowledgeandskillsandidentifythesharedcorefacilitieseach partnerwillcontributetoSACREN,tosupportitsresearchprojects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory Grants (P20)
Project #
1P20CA217231-01
Application #
9336575
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2017-09-15
Project End
2019-08-31
Budget Start
2017-09-15
Budget End
2018-08-31
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Instituto de Efectividad Clinica Y Sanit
Department
Type
DUNS #
978136497
City
Ciudad de Buenos Aires
State
Country
Argentina
Zip Code
C1414CPV

  Publications

Benziger, Catherine P; Zavala-Loayza, José Alfredo; Bernabe-Ortiz, Antonio et al. (2018) Low prevalence of ideal cardiovascular health in Peru. Heart 104:1251-1256