The goal of this third Delaware INBRE renewal proposal is to take another major step towards improving health care in the State by extending the ongoing work of the DE-INBRE in building a statewide biomedical research capability. The project will continue to strengthen the research expertise and infrastructure of the DE-INBRE academic and clinical partner institutions - the University of Delaware, Delaware State University, Delaware Technical Community College, Wesley College, Christiana Care Health System and Nemours/A.I. duPont Hospital for Children. In addition to a growing statewide bioinformatics program, three biomedical Research Themes will be pursued through developmental research projects: these programs will focus on cancer, cardiovascular disease and neurosciences. Funds are provided to support junior faculty, postdoctoral and graduate students engaged in mentored research projects within each Research Theme. The Research Themes are supported by a statewide biomedical infrastructure developed under the current INBRE, but with considerably enhanced Bioinformatics and Centralized,Instrumentation Cores. An Education and Professional Development Core will provide engaging research opportunities for students from the state's undergraduate institutions and community colleges, thereby developing a pipeline of students pursuing careers in the health care industry and enhancing the biomedical knowledge of the state's workforce.
The Specific Aims of the DE-INBRE-3 proposal are to: (1) Foster a statewide Network to create a strong, sustainable biomedical research capability in Delaware; (2) Develop independent and inter-dependent researchers and institutions that thrive within the Network; (3) Institutionalize DE-INBRE initiatives by transitioning programs into the partner institutions; and (4) Enhance the biomedical science and technology knowledge of the state's workforce. The five DE-INBRE Core Sections described in this proposal - Bioinformatics Core; Developmental Research Project Program; Centralized Research Instrumentation Core; Education and Professional Development Core; and Alterations and Renovations Core - will be supported by an effective Administrative Core. This renewal proposal will provide critical funding to continue building biomedical research infrastructure needed to develop the current programs toward a sustainable research capability in Delaware that will have significant impact on the economy of the state and its institutions and the health of Delaware's citizens.
The Delaware INBRE program focuses on addressing the region's greatest risks to health. Basic and translational research in cancer, heart disease and brain function is supported, and researchers, clinicians and students are trained within a well-integrated network of academic and clinical institutions across the state. The goal is to further strengthen Delaware's health research efforts, create health-related jobs and improve the lives of Delawareans.
|Graham, Brian T; Moore, Axel C; Burris, David L et al. (2018) Mapping the spatiotemporal evolution of solute transport in articular cartilage explants reveals how cartilage recovers fluid within the contact area during sliding. J Biomech 71:271-276|
|Cogburn, Larry A; Trakooljul, Nares; Chen, Chuming et al. (2018) Transcriptional profiling of liver during the critical embryo-to-hatchling transition period in the chicken (Gallus gallus). BMC Genomics 19:695|
|D'Souza, Malcolm J; Bautista, Riza C; Wentzien, Derald E (2018) Data Talks: Obesity-Related Influences on US Mortality Rates. Res Health Sci 3:65-78|
|Çelen, ?rem; Doh, Jung H; Sabanayagam, Chandran R (2018) Effects of liquid cultivation on gene expression and phenotype of C. elegans. BMC Genomics 19:562|
|Pichler, Klemens; Warner, Kate; Magrane, Michele et al. (2018) SPIN: Submitting Sequences Determined at Protein Level to UniProt. Curr Protoc Bioinformatics 62:e52|
|Siddam, Archana D; Gautier-Courteille, Carole; Perez-Campos, Linette et al. (2018) The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development. PLoS Genet 14:e1007278|
|Bhat, Anupama; Huan, Kewei; Cooks, Tiana et al. (2018) Probing Interactions between AuNPs/AgNPs and Giant Unilamellar Vesicles (GUVs) Using Hyperspectral Dark-field Microscopy. Int J Mol Sci 19:|
|Schultz, Mark L; Tecedor, Luis; Lysenko, Elena et al. (2018) Modulating membrane fluidity corrects Batten disease phenotypes in vitro and in vivo. Neurobiol Dis 115:182-193|
|Maresca, Julia A; Miller, Kelsey J; Keffer, Jessica L et al. (2018) Distribution and Diversity of Rhodopsin-Producing Microbes in the Chesapeake Bay. Appl Environ Microbiol 84:|
|Davis, Stephani A; Itaman, Sheed; Khalid-Janney, Christopher M et al. (2018) TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics. Neurosci Lett 678:8-15|
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